PXD024829 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The proteome and phosphoproteome of acute stress in the mouse hippocampus |
Description | The acute stress response mobilizes energy to meet situational demands and re-establish homeostasis. However, little is known about the nature and dynamics of the underlying molecular cascades. We used a brief forced swim exposure to trigger a strong stress response in mice, which transiently increases anxiety, but does not lead to lasting maladaptive behavioral changes. Using multiomic profiling we characterize the stress-induced molecular events in the hippocampus over time, across molecular scales, and down to the level of cell types and single cells. Our results unveil the complexity and specificity of the healthy stress response, with widespread changes in protein phosphorylation and gene transcription, but tightly regulated protein translation. All observed molecular events resolve efficiently within 4 hours after initiation of stress. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_05:31:10.877.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Lukas von Ziegler |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-18 03:47:59 | ID requested | |
1 | 2022-02-09 05:47:42 | announced | |
⏵ 2 | 2024-10-22 05:31:11 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: mouse, hippocampus, phosphoproteome, acute stress, proteome |
Contact List
Johannes Bohacek |
contact affiliation | Laboratory of Molecular and Behavioral Neuroscience, Institute for Neuroscience, Department of Health Sciences and Technology, ETH Zurich, Switzerland |
contact email | johannes.bohacek@hest.ethz.ch |
lab head | |
Lukas von Ziegler |
contact affiliation | Swiss Federal Institute of Technology |
contact email | lukasvonziegler@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024829
- Label: PRIDE project
- Name: The proteome and phosphoproteome of acute stress in the mouse hippocampus