PXD024638 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Venom proteomic analysis of two medically important Nigerian viperidae (Echis ocellatus and Bitis arietans) snake species |
Description | Hydrophilic interaction liquid chromatography coupled with LC- MS/MS was used to analyze the crude venom extracts of Echis ocellatus (Carpet viper) and Bitis arietans (Puff adder). The gel-free proteomic analysis of the crude venom extracts from E. ocellatus and B. arietans yielded the identification of 86 and 80 proteins, respectively. Seventy- nine proteins were common between the two snake species with a 90.8% similarity. The identified proteins belong to 12 protein families where serine proteases (22.31%) and metalloproteinases (21.06%) were the dominant proteins in the venom of B. arietans. Metalloproteinases (34.84%), phospholipase A 2 s (25.69%) and serine proteases (17.25%) represents the major toxins in the E. ocellatus venom. This study provides some valuable insights into the toxin families to be neutralized in case of envenomation. |
HostingRepository | PRIDE |
AnnounceDate | 2021-03-11 |
AnnouncementXML | Submission_2021-03-10_21:50:56.451.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD024638 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Emeka Dingwoke |
SpeciesList | scientific name: Bitis arietans; NCBI TaxID: 8692; scientific name: Echis ocellatus; NCBI TaxID: 99586; |
ModificationList | No PTMs are included in the dataset |
Instrument | Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-10 03:25:31 | ID requested | |
⏵ 1 | 2021-03-10 21:50:56 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Snakebite, neglected tropical disease, viperidae, Bitis arietans, Echi ocellatus, snake venom, proteomic, mass spectrometry. |
Contact List
Emeka John Dingwoke |
contact affiliation | Department of Biochemistry/Venom, Antivenom and Natural Toxins Research Centre, Ahmadu Bello University, Zaria |
contact email | dinhimself@yahoo.com |
lab head | |
Emeka Dingwoke |
contact affiliation | Department of Biochemistry Venom, Antivenom and Natural Toxins Research Centre, Ahmadu Bello University, Zaria, Nigeria. |
contact email | dinhimself@yahoo.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024638
- Label: PRIDE project
- Name: Venom proteomic analysis of two medically important Nigerian viperidae (Echis ocellatus and Bitis arietans) snake species