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PXD024638

PXD024638 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleVenom proteomic analysis of two medically important Nigerian viperidae (Echis ocellatus and Bitis arietans) snake species
DescriptionHydrophilic interaction liquid chromatography coupled with LC- MS/MS was used to analyze the crude venom extracts of Echis ocellatus (Carpet viper) and Bitis arietans (Puff adder). The gel-free proteomic analysis of the crude venom extracts from E. ocellatus and B. arietans yielded the identification of 86 and 80 proteins, respectively. Seventy- nine proteins were common between the two snake species with a 90.8% similarity. The identified proteins belong to 12 protein families where serine proteases (22.31%) and metalloproteinases (21.06%) were the dominant proteins in the venom of B. arietans. Metalloproteinases (34.84%), phospholipase A 2 s (25.69%) and serine proteases (17.25%) represents the major toxins in the E. ocellatus venom. This study provides some valuable insights into the toxin families to be neutralized in case of envenomation.
HostingRepositoryPRIDE
AnnounceDate2021-03-11
AnnouncementXMLSubmission_2021-03-10_21:50:56.451.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD024638
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterEmeka Dingwoke
SpeciesList scientific name: Bitis arietans; NCBI TaxID: 8692; scientific name: Echis ocellatus; NCBI TaxID: 99586;
ModificationListNo PTMs are included in the dataset
InstrumentOrbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02021-03-10 03:25:31ID requested
12021-03-10 21:50:56announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Snakebite, neglected tropical disease, viperidae, Bitis arietans, Echi ocellatus, snake venom, proteomic, mass spectrometry.
Contact List
Emeka John Dingwoke
contact affiliationDepartment of Biochemistry/Venom, Antivenom and Natural Toxins Research Centre, Ahmadu Bello University, Zaria
contact emaildinhimself@yahoo.com
lab head
Emeka Dingwoke
contact affiliationDepartment of Biochemistry Venom, Antivenom and Natural Toxins Research Centre, Ahmadu Bello University, Zaria, Nigeria.
contact emaildinhimself@yahoo.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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