PXD024625 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder |
Description | We identified that peroxins were still expressed in Zellweger Spectrum Disorder (ZSD) and a subset of them accumulated on the mitochondrial membrane, which resulted in gross mitochondrial abnormalities and impaired mitochondrial metabolic function. In this complexome analysis we detected several peroxins in the mitochondrial fraction in the absence of functional peroxisomes and that this accumulation is exacerbated by the loss of the mitochondrial extractase Msp1. In addition, we observed that specific peroxisomal matrix proteins localize to the mitochondria, which suggest that a functional peroxisomal docking and import complex assembles on the mitochondria in the absence of peroxisomes. |
HostingRepository | PRIDE |
AnnounceDate | 2021-06-25 |
AnnouncementXML | Submission_2021-06-25_00:42:14.844.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Ilka Wittig |
SpeciesList | scientific name: Saccharomyces cerevisiae (Baker's yeast); NCBI TaxID: 4932; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-03-10 00:05:37 | ID requested | |
⏵ 1 | 2021-06-25 00:42:15 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: LC-MSMS, complexome profiling, mitochondria, peroxisomes, peroxisomal biogenesis disorder, peroxisomal import, mitocondrial quality control |
Contact List
Jared Rutter |
contact affiliation | Medical School, Department of Biochemistry, University of Utah, Salt Lake City, USA |
contact email | rutter@biochem.utah.edu |
lab head | |
Ilka Wittig |
contact affiliation | Functional Proteomics, Goethe University, Frankfurt am Main , Germany |
contact email | wittig@med.uni-frankfurt.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024625
- Label: PRIDE project
- Name: The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder