PXD024346 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy) |
Description | Recent improvements in the analysis ancient biomolecules from human remains and associated dental calculus have provided new insights into the prehistoric diet and past genetic diversity of our species. Here we present a “multi-omics” study, integrating genomic and proteomic analyses of two post-Last Glacial Maximum (LGM) individuals from San Teodoro cave (Italy), to reconstruct their lifestyle and the post-LGM resettlement of Europe. Our analyses show genetic homogeneity in Sicily during the Palaeolithic, representing a hitherto unknown Italian genetic lineage within the previously identified “Villabruna cluster”. We argue that this lineage took refuge in Italy during the LGM, followed by a subsequent spread to central-western Europe. Analyses of dental calculus using genomics and proteomics showed a similar oral microbiome composition as Neandertals, but distinct from later foragers and farmers, revealing also a diet based on mammals, fish and plants. Our results demonstrate the power of using a multi-omics approach in the study of prehistoric human populations. |
HostingRepository | PRIDE |
AnnounceDate | 2022-10-27 |
AnnouncementXML | Submission_2022-10-27_02:58:27.137.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | MeaghanMackie |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | monohydroxylated residue; deamidated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2021-02-24 02:18:38 | ID requested | |
⏵ 1 | 2022-10-27 02:58:27 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: dental calculus, bone, Human, Sicily, Italy, archaeology, LC-MS/MS |
Contact List
EnricoCappellini |
contact affiliation | The Globe Institue, University of Copenhagen |
contact email | ecappellini@sund.ku.dk |
lab head | |
MeaghanMackie |
contact affiliation | University of Copenhagen |
contact email | meaghan@palaeome.org |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/10/PXD024346 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD024346
- Label: PRIDE project
- Name: Genomic ancestry, diet and microbiomes of Upper Palaeolithic hunter-gatherers from San Teodoro cave (Sicily, Italy)