PXD024219

PXD024219 is an original dataset announced via ProteomeXchange.

Title	Network analysis of the CSF proteome characterises convergent pathways of cellular dysfunction in ALS
Description	Amyotrophic lateral sclerosis is a clinical syndrome with complex biological determinants, but which in most cases is characterised by TDP-43 pathology. The identification in CSF of a protein signature of TDP-43 network dysfunction would have the potential to inform the identification of new biomarkers and therapeutic targets. We compared CSF proteomic data from patients with ALS (n=41), Parkinson's disease (n=19) and healthy control participants (n=20). Weighted correlation network analysis was used to identify modules within the CSF protein network and combined with gene ontology enrichment analysis to functionally annotate module proteins. Analysis of module eigenproteins and differential correlation analysis of the CSF protein network was used to compare ALS and Parkinson's disease protein co-correlation with healthy controls. In order to monitor temporal changes in the CSF proteome, we performed longitudinal analysis of the CSF proteome in a subset of ALS patients. Alterations in the co-correlation network in CSF samples identified a set of pathways known to be associated with TDP-43 dysfunction in the pathogenesis of ALS, with important implications for therapeutic targeting and biomarker development.
HostingRepository	PRIDE
AnnounceDate	2021-03-16
AnnouncementXML	Submission_2021-03-16_06:35:28.701.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD024219
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Philip Charles
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; deamidated residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2021-02-17 10:22:14	ID requested
⏵ 1	2021-03-16 06:35:29	announced

Dataset with its publication pending

submitter keyword: Cerebrospinal fluid, amyotrophic lateral sclerosis, motor neuron disease, proteome, WGCNA, network analysis

Martin Turner
contact affiliation	Nuffield Department of Clinical Neurosciences, University of Oxford, UK
contact email	martin.turner@ndcn.ox.ac.uk
lab head
Philip Charles
contact affiliation	University of Oxford
contact email	philip.charles@ndm.ox.ac.uk
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD024219
     1. Label: PRIDE project
     2. Name: Network analysis of the CSF proteome characterises convergent pathways of cellular dysfunction in ALS