PXD023422

PXD023422 is an original dataset announced via ProteomeXchange.

Title	Fluvastatin mitigates SARS-CoV-2 infection in human lung cells
Description	Clinical data of patients suffering from COVID-19 have indicated that statin therapy, used to treat hypercholesterolemia, is associated with a better clinical outcome. We therefore investigated the effect of statins on SARS-CoV-2 infection in human lung cells and found that fluvastatin inhibited coronavirus infection, while other tested statins did not. Fluvastatin inhibited high and low pathogenic coronaviruses in vitro and ex vivo in a dose-dependent manner. Proteomic analyses of infected versus uninfected lung epithelial cells treated with fluvastatin, simvastatin, or rosuvastatin revealed that all tested statins modulated the cholesterol synthesis pathways without compromising the innate antiviral immune response. Strikingly, fluvastatin treatment uniquely affected the proteome of SARS CoV 2 infected cells, specifically downregulating proteins that modulate protein translation and viral replication. These results suggest that statin therapy poses no additional risk to individuals exposed to SARS-CoV-2 and that fluvastatin may have a moderate beneficial effect on SARS CoV-2 infection by modulating protein translation.
HostingRepository	PRIDE
AnnounceDate	2021-12-07
AnnouncementXML	Submission_2021-12-07_07:28:00.315.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Lothar Jaensch
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	methylthiolated residue; monohydroxylated residue
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2021-01-06 00:02:50	ID requested
⏵ 1	2021-12-07 07:28:00	announced

Dataset with its publication pending

ProteomeXchange project tag: Sars-cov-2, Covid-19

submitter keyword: SARS-CoV-2, COVID-19, virus, cholesterol, hypercholesteremia, statin, risk factor, proteomics, air-liquid-interface culture, cholesterol, fluvastatin

Lothar Jaensch
contact affiliation	Helmholtz Centre for Infection Reasearch, Structure and Function of proteins Division, Cellular Proteomics Group, Germany
contact email	Lothar.jaensch@helmholtz-hzi.de
lab head
Lothar Jaensch
contact affiliation	HZI
contact email	Lothar.Jaensch@Helmholtz-HZI.de
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD023422
     1. Label: PRIDE project
     2. Name: Fluvastatin mitigates SARS-CoV-2 infection in human lung cells