PXD023228

PXD023228 is an original dataset announced via ProteomeXchange.

Title	Proteomic analysis of the secretome of seven Leishmania species
Description	This study provides a comprehensive analysis of the secretome of seven different Leishmania species (six main human pathogenic species: L. donovani, L. infantum, L. braziliensis, L. major, L. amazonensis, L. tropica) and L. tarentolae, non-pathogenic to humans, produced by promastigotes cultured in serum-free conditions. The exhaustive analysis of the protein content of the secretome using mass spectrometry led to the identification of common and unique proteins, as well as useful insights on the relation between secretome content and pathogenesis. The biological relevance of the secretome is undeniable and, in the particular case of Leishmania parasites, it is a crucial player in the host-pathogen interactions which dictate the outcome of infection and disease severity. This study actively contributes to current knowledge on Leishmania biology and the generated datasets are an addition to current databases, associating the identified proteins with subcellular localization and putative extracellular functions.
HostingRepository	PRIDE
AnnounceDate	2021-11-29
AnnouncementXML	Submission_2021-11-29_06:19:32.535.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Functional Proteomics Platform FPP
SpeciesList	scientific name: Leishmania ; NCBI TaxID: 5658;
ModificationList	monohydroxylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap XL

Revision	Datetime	Status	ChangeLog Entry
0	2020-12-18 07:05:55	ID requested
⏵ 1	2021-11-29 06:19:32	announced

Dataset with its publication pending

submitter keyword: Leishmaniasis, promastigote,Leishmania, secretome

Jean-Loup Lemesre
contact affiliation	UMR177 INTERTRYP, IRD, Montpellier, France
contact email	jean-loup.lemesre@ird.fr
lab head
Functional Proteomics Platform FPP
contact affiliation	FPP CNRS
contact email	contact@fpp.cnrs.fr
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD023228

PRIDE project URI

• PRIDE
  1. PXD023228
     1. Label: PRIDE project
     2. Name: Proteomic analysis of the secretome of seven Leishmania species