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PXD023064

PXD023064 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSystematic HLA Epitope Ranking Pan Algorithm (SHERPA)
DescriptionTo generate high quality training data for our MHC binding and presentation prediction models, we stably transfected alleles into HLA-null, K562 to create mono-allelic cell lines. Then, we performed immunoprecipitation using W6/32 antibody and gently eluted the peptides. Finally, they were analyzed using LC-MSMS. To validate the performance of our prediction algorithms, we also processed 12 lung and colorectal tumor tissues with the same protocol.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:22:55.427.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSean Boyle
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListacetylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentOrbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-12-11 04:35:00ID requested
12021-06-14 16:56:02announced
22024-10-22 05:22:55announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: binding prediction, MHC, peptide, immunopeptidomics, tumor,LC-MSMS, mono-allelic
Contact List
Sean Michael Boyle
contact affiliationPersonalis, Inc.
contact emailsean.boyle@personalis.com
lab head
Sean Boyle
contact affiliationPersonalis Inc.
contact emailpsnl_dash@personalis.com
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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