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PXD022808

PXD022808 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleProteomic alterations in oral cancer patients delineated by tobacco using habits
DescriptionMolecular alterations induced by tobacco usage are not well characterized in oral squamous cell carcinoma. Tobacco consumption in chewing or smoking forms is a known risk factor in oral cancer. To understand proteomic changes due to tobacco usage in oral cancer patients we carried out comparative proteomic analysis in oral cancer patients who had history of tobacco using habits (patients who chewed tobacco and patients who smoked tobacco) and those with no history of tobacco consumption. Proteomic analysis resulted in the quantification of 5,848 proteins in smoker cohort, 5,216 in chewer, and 5,320 in non-user cohort. Among these 443, 72 and 139 were significantly dysregulated proteins (p-value≤ 0.05 and 2-fold change) in smoker, chewer and non-user cohorts, respectively. Gene ontology and pathway analysis of significantly dysregulated proteins revealed enrichment of distinct biological processes and pathways in each patient cohort. Proteins associated with collagen formation and antigen processing/presentation pathway were dysregulated in oral cancer patients who smoked tobacco, while keratinization process was enriched in patients who chewed tobacco. We also observed dysregulated proteins in non-users to be involved in ECM proteoglycans, metabolism of carbohydrates and glycosaminoglycans. Immune signaling pathways and muscle contraction were identified as common events dysregulated in all three cohorts. This study helps us to decipher the proteomic alterations induced by tobacco usage in oral cancer patients and will assist in identification of early detection markers to identify high risk population
HostingRepositoryPRIDE
AnnounceDate2022-03-15
AnnouncementXMLSubmission_2022-03-15_11:04:49.970.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAditi Chatterjee
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListTMT6plex-126 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue
InstrumentQ Exactive HF-X
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-30 03:58:23ID requested
12022-03-15 11:04:50announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Oral cancer
Tobacco
Proteomics
Immune signaling
Muscle contraction, smoking
Contact List
Aditi Chatterjee
contact affiliationInstitute of Bioinformatics, Bangalore
contact emailaditixchatterjee@gmail.com
lab head
Aditi Chatterjee
contact affiliationInstitute of Bioinformatics, Bangalore, Karnataka, India
contact emailaditixchatterjee@gmail.com
dataset submitter
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Dataset FTP location
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