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PXD022708

PXD022708 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleQuantitative chemical proteomics of Leishmania mexicana
DescriptionWe report the first systematic study of the effect of Hsp90 inhibition on the global protein synthesis in Leishmania parasites using an integrated chemical biology approach. Heat shock protein 90 (Hsp90) is a conserved molecular chaperone responsible for the folding of newly synthesised proteins. It is regarded as a master regulator of protein homeostasis of the cell, and its inhibition has been proposed to affect functions of a large array of its client proteins. We showed that the Hsp90 inhibition affects synthesis of many Leishmania proteins, with important chaperones and virulence factors showing an overall increased relative expression whilst many ribosomal proteins showing a down-regulation. This study defines the Leishmania parasite’s response to Hsp90 inhibition at its nascent global protein synthesis and provides a rich resource for future studies on Leishmania biology and antileishmanial drug development.
HostingRepositoryPRIDE
AnnounceDate2021-04-23
AnnouncementXMLSubmission_2021-04-23_08:51:42.805.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterKalesh Karunakaran
SpeciesList scientific name: Leishmania mexicana mexicana; NCBI TaxID: 44270;
ModificationListNo PTMs are included in the dataset
InstrumentTripleTOF 5600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-24 07:56:27ID requested
12021-04-23 08:51:43announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Leishmania, iTRAQ
Contact List
Kalesh Karunakaran
contact affiliationDepartment of Chemistry, Durham University, Durham, UK
contact emailkalesh.karunakaran@durham.ac.uk
lab head
Kalesh Karunakaran
contact affiliationDurham University
contact emailkalesh.karunakaran@durham.ac.uk
dataset submitter
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Dataset FTP location
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