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PXD022408

PXD022408 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCryo-EM structural analysis of FADD: Caspase-8 complexes defines the catalytic dimer architecture for co-ordinated control of cell fate
DescriptionUncovering the molecular architecture of the core FADD:Caspase-8 complex and how this is altered by regulatory partners, such as the cell death inhibitor c-FLIP, is essential to understand co-ordination of cell fate. Here, using electron microscopy, we visualize for the first time fulllength procaspase-8 in a complex with FADD. Our structural analysis reveals how the FADDnucleated tandem death effector domain (tDED) helical filament is required to correctly orientate procaspase-8 catalytic domains, enabling activation via anti-parallel dimerization.
HostingRepositoryPRIDE
AnnounceDate2021-02-08
AnnouncementXMLSubmission_2021-02-08_00:59:01.xml
DigitalObjectIdentifierhttps://dx.doi.org/10.6019/PXD022408
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterRebekah Jukes-Jones
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListNo PTMs are included in the dataset
InstrumentSynapt MS
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-06 07:03:52ID requested
12021-02-08 00:59:01announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Cell death. DISC, FADD, Caspase 8, c-Flip Complex, EM, Structure
Contact List
Marion M. MacFarlane
contact affiliationMRC Toxicology Unit, University of Cambridge, Hodgkin Building, Lancaster Road, Leicester, LE1 9HN, UK
contact emailmm2312@mrc-tox.cam.ac.uk
lab head
Rebekah Jukes-Jones
contact affiliationMRC Toxicology Unit
contact emailrj396@mrc-tox.cam.ac.uk
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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