PXD022400 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Venom proteome of the limacodid caterpillar Doratifera vulnerans |
Description | Caterpillars of moths in the family Limacodidae produce pain-inducing defensive venoms that have evolved independently to previously characterised lepidopteran venoms, but their composition and mechanism of action are unknown. Here, we examine the limacodid venom system using the species Doratifera vulnerans as a model. Large secretory cells at the base of each spine produce a complex venom (151 proteinaceous toxins in 59 families) that consists predominantly of peptides <10 kDa. Three abundant families of venom peptides (vulnericins) are analogues of adipokinetic hormone/corazonin-like neurohormone that activate the endogenous receptor with picomolar efficacy (Family 1); cationic peptides related to cecropin that disrupt lipid bilayers, induce pain, and kill bacteria and helminths (Family 2); and disulfide-rich knottins (Family 3). Our data reveal convergent molecular evolution between limacodids, hymenopterans, and arachnids, and highlight the potential of Limacodidae for peptide biodiscovery. |
HostingRepository | PRIDE |
AnnounceDate | 2021-04-12 |
AnnouncementXML | Submission_2021-04-12_07:45:58.148.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Andrew Walker |
SpeciesList | scientific name: Doratifera vulnerans; NCBI TaxID: 1372962; |
ModificationList | amidated residue; 2-pyrrolidone-5-carboxylic acid (Gln) |
Instrument | TripleTOF 5600; TripleTOF 6600 |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-11-06 01:39:17 | ID requested | |
⏵ 1 | 2021-04-12 07:45:58 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: venom |
Lepidoptera |
Limacodidae |
caterpillar |
peptide |
toxin |
Contact List
Glenn F. King |
contact affiliation | NHMRC Principal Research Fellow Editor-in-Chief, Toxicon & Toxicon:X Theme Leader, Australian Research Council Centre of Excellence for Innovations in Peptide & Protein Science Deputy Head, Division of Chemistry & Structural Biology Institute for Molecular Bioscience The University of Queensland |
contact email | glenn.king@imb.uq.edu.au |
lab head | |
Andrew Walker |
contact affiliation | University of Queensland |
contact email | a.walker@uq.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD022400
- Label: PRIDE project
- Name: Venom proteome of the limacodid caterpillar Doratifera vulnerans