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PXD022400

PXD022400 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleVenom proteome of the limacodid caterpillar Doratifera vulnerans
DescriptionCaterpillars of moths in the family Limacodidae produce pain-inducing defensive venoms that have evolved independently to previously characterised lepidopteran venoms, but their composition and mechanism of action are unknown. Here, we examine the limacodid venom system using the species Doratifera vulnerans as a model. Large secretory cells at the base of each spine produce a complex venom (151 proteinaceous toxins in 59 families) that consists predominantly of peptides <10 kDa. Three abundant families of venom peptides (vulnericins) are analogues of adipokinetic hormone/corazonin-like neurohormone that activate the endogenous receptor with picomolar efficacy (Family 1); cationic peptides related to cecropin that disrupt lipid bilayers, induce pain, and kill bacteria and helminths (Family 2); and disulfide-rich knottins (Family 3). Our data reveal convergent molecular evolution between limacodids, hymenopterans, and arachnids, and highlight the potential of Limacodidae for peptide biodiscovery.
HostingRepositoryPRIDE
AnnounceDate2021-04-12
AnnouncementXMLSubmission_2021-04-12_07:45:58.148.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterAndrew Walker
SpeciesList scientific name: Doratifera vulnerans; NCBI TaxID: 1372962;
ModificationListamidated residue; 2-pyrrolidone-5-carboxylic acid (Gln)
InstrumentTripleTOF 5600; TripleTOF 6600
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-11-06 01:39:17ID requested
12021-04-12 07:45:58announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: venom
Lepidoptera
Limacodidae
caterpillar
peptide
toxin
Contact List
Glenn F. King
contact affiliationNHMRC Principal Research Fellow Editor-in-Chief, Toxicon & Toxicon:X Theme Leader, Australian Research Council Centre of Excellence for Innovations in Peptide & Protein Science Deputy Head, Division of Chemistry & Structural Biology Institute for Molecular Bioscience The University of Queensland
contact emailglenn.king@imb.uq.edu.au
lab head
Andrew Walker
contact affiliationUniversity of Queensland
contact emaila.walker@uq.edu.au
dataset submitter
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Dataset FTP location
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