PXD021646 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes |
Description | STRIPAK is a highly conserved eukaryotic signalling complex controlling a wide range of developmental processes in microorganisms as well as humans. This study uses iTRAQ-based proteomic and phosphoproteomic analyses to expand the identification of differentially phosphorylated proteins, comparing the wildtype proteome of the model fungus S. macorspora to those from three STRIPAK single- and double deletion mutants. Among the differentially phosphorylated proteins, we detected Gul1, a homolog of GUL-1 from N. crassa and SSD1 from yeast. In this study, we further provide a functional analysis of Gul1, showing it controls sexual development and hyphal morphology in a phosphorylation dependent manner. |
HostingRepository | PRIDE |
AnnounceDate | 2020-09-24 |
AnnouncementXML | Submission_2020-09-24_01:50:32.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Bernhard Blank-Landeshammer |
SpeciesList | scientific name: Sordaria macrospora k-hell; NCBI TaxID: 771870; |
ModificationList | phosphorylated residue; iTRAQ8plex-116 reporter+balance reagent acylated residue; monohydroxylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-09-23 06:56:51 | ID requested | |
⏵ 1 | 2020-09-24 01:50:32 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Sordaria macrospora, LC-MSMS, Phosphoproteomics, iTRAQ |
Contact List
Prof. Dr. Albert Sickmann |
contact affiliation | Leibniz-Institut für Analytische Wissenschaften – ISAS – e.V. |
contact email | sickmann@isas.de |
lab head | |
Bernhard Blank-Landeshammer |
contact affiliation | Leibniz-Institut für Analytische Wissenschaften - ISAS e.V. |
contact email | blank.bernhard@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/09/PXD021646 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021646
- Label: PRIDE project
- Name: The STRIPAK signaling complex regulates dephosphorylation of GUL1, an RNA-binding protein that shuttles on endosomes