PXD021588 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Comparative Host-Coronavirus Protein Interaction Networks Reveal Pan-Viral Disease Mechanisms |
Description | Abstract: The COVID-19 (Coronavirus disease-2019) pandemic, caused by the SARS-CoV-2 coronavirus, has highlighted emergent viruses as significant threats to public health and the global economy. SARS-CoV-2 is closely related to the more lethal but less transmissible coronaviruses SARS-CoV-1 and MERS-CoV. Here, we have carried out comparative viral-human protein-protein interaction and viral protein localization analysis for all three viruses. We find that proteins often do not change localization across viruses but their sequence divergence dictates differences in host interactions. Functional genetic screening identified host factors that functionally impinge on coronavirus proliferation, including Tom70, a mitochondrial chaperone protein that interacts with both SARS-CoV-1 and SARS-CoV-2 Orf9b, an interaction we structurally characterized using cryoEM. Combining genetically validated host factors with both COVID-19 patient genetic data and medical billing records identified important molecular mechanisms (IL-17 regulation) and drug treatments (sigma-1 receptor ligands) that merit further molecular and clinical study. |
HostingRepository | PRIDE |
AnnounceDate | 2023-11-14 |
AnnouncementXML | Submission_2023-11-14_07:09:27.018.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Danielle Swaney |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | No PTMs are included in the dataset |
Instrument | Q Exactive Plus |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-09-21 02:47:38 | ID requested | |
1 | 2020-10-16 00:56:42 | announced | |
2 | 2020-10-26 08:35:50 | announced | 2020-10-26: Updated publication reference for DOI(s): 10.1126/science.abe9403. |
⏵ 3 | 2023-11-14 07:09:27 | announced | 2023-11-14: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Sars-cov-2, Covid-19 |
submitter keyword: AP-MS,coronavirus |
Contact List
Nevan Krogan |
contact affiliation | UCSF |
contact email | daniswan@gmail.com |
lab head | |
Danielle Swaney |
contact affiliation | UCSF |
contact email | daniswan@gmail.com |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021588
- Label: PRIDE project
- Name: Comparative Host-Coronavirus Protein Interaction Networks Reveal Pan-Viral Disease Mechanisms