PXD021569
PXD021569 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Sex-specific effects of in vitro fertilization on adult metabolic phenotypes and hepatic transcriptomic and proteomic pathways in mouse |
Description | Although in vitro fertilization (IVF) is associated with adverse perinatal outcomes, an increasing concern is the long-term health implications. We augmented our IVF mouse model to longitudinally investigate cardiometabolic outcomes in offspring from optimal neonatal litter sizes. We found that IVF-conceived females had higher body weight and cholesterol levels compared to naturally-conceived females, whereas IVF-conceived males had higher levels of triglycerides and insulin, and increased body fat composition. Through transcriptomics and proteomics of adult liver, we identified sexually-dimorphic dysregulation of the sterol regulatory element binding protein (SREBP) pathways that are associated with the sex-specific phenotypes. We also found that global loss of DNA methylation in placenta was linked to higher cholesterol levels in IVF-conceived females. Our findings indicate that IVF procedures have long-lasting sex-specific effects on metabolic health of offspring and lay the foundation to utilize the placenta as a predictor of long-term outcomes. |
HostingRepository | MassIVE |
AnnounceDate | 2021-03-16 |
AnnouncementXML | Submission_2021-03-16_14:47:43.429.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Josue Baeza |
SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
ModificationList | Carbamidomethyl |
Instrument | instrument model |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-09-18 14:29:54 | ID requested | |
⏵ 1 | 2021-03-16 14:47:43 | announced |
Publication List
no publication |
Keyword List
submitter keyword: DIA, Assisted Reproductive Technologies, developmental origins of health and disease (DOHaD) |
Contact List
Bartolomei, Marisa | |
---|---|
contact affiliation | University of Pennsylvania |
contact email | bartolom@pennmedicine.upenn.edu |
lab head | |
Josue Baeza | |
contact affiliation | University of Pennsylvania |
contact email | baeza@pennmedicine.upenn.edu |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000086177/ |