PXD021371 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | DCLK1 small extracellular vesicle proteome |
Description | Doublecortin-like kinase 1 (DCLK1) is a putative cancer stem cell marker, a promising diagnostic and prognostic maker for malignant tumors and a proposed driver gene for gastric cancer. Here we show that DCLK1 expression in the gastric cancer cell line MKN1 impacts EV biogenesis both quantitatively and qualitatively in a kinase dependent manner, revealing a hitherto unknown role for this putative oncogenic kinase. Importantly, the proteome of EVs isolated from DCLK1 expressing gastric cancer cells is enriched for proteins involved in tumor-promoting biological processes, raising the prospect of establishing DCLK1 as a novel anti-cancer target. |
HostingRepository | PRIDE |
AnnounceDate | 2021-03-23 |
AnnouncementXML | Submission_2021-03-22_23:10:57.792.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | david greening |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | acetylated residue; iodoacetamide derivatized residue |
Instrument | Q Exactive HF |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-09-09 01:09:50 | ID requested | |
⏵ 1 | 2021-03-22 23:10:58 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: DCLK1, proteomics, exosomes, extracellular vesicles, migration |
Contact List
David Greening |
contact affiliation | Baker Institute |
contact email | david.greening@baker.edu.au |
lab head | |
david greening |
contact affiliation | Baker Heart and Diabetes Inst. |
contact email | david.greening@baker.edu.au |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD021371
- Label: PRIDE project
- Name: DCLK1 small extracellular vesicle proteome