PXD019914
PXD019914 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Glycoproteomic Characterization of Human High-Grade Serous Ovarian Cancer |
Description | Inter-tumor heterogeneity is a reflective of the coalescence of a myriad of genomic, transcriptional, translational, and post-translational molecular features. To investigate the contribution of protein glycosylation in tumor heterogeneity in high-grade serous ovarian carcinoma (HGSC), we performed mass-spectrometry (MS)-based glycoproteomic characterization of 119 TCGA HGSC tissues. These HGSC tumor tissues have been previously characterized at the genomic and transcriptomic levels, as well as the proteomic and phosphoproteomic levels, by The Cancer Genomic Atlas (TCGA) consortia and the Clinical Proteomic Tumor Analysis Consortium (CPTAC), respectively. Employing two glycoproteomic strategies, Solid-Phase Extraction of Glycosite-containing peptides (SPEG) for glycosite analysis, and intact glycopeptides for investigation of glycosite-specific glycans (IGPs), we profiled the N-linked glycoproteome in HGSCs, identifying and quantifying glycosites and attached glycan structures. |
HostingRepository | MassIVE |
AnnounceDate | 2020-06-20 |
AnnouncementXML | Submission_2020-06-20_06:11:12.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Jianbo Pan |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | deglycosylated asparagine |
Instrument | Q Exactive; Orbitrap Fusion Lumos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2020-06-19 21:40:19 | ID requested | |
⏵ 1 | 2020-06-20 06:11:12 | announced |
Publication List
no publication |
Keyword List
submitter keyword: Glycoproteomics, Tumor heterogeneity, High-Grade Serous Ovarian Carcinoma (HGSC) , Glycosylation, Mass Spectrometry |
Contact List
Hui Zhang | |
---|---|
contact affiliation | Department of Pathology, School of Medicine, Johns Hopkins University |
contact email | huizhang@jhu.edu |
lab head | |
Jianbo Pan | |
contact affiliation | Johns Hopkins University |
contact email | panjianbo87@gmail.com |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000085613/ |