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PXD019914

PXD019914 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleGlycoproteomic Characterization of Human High-Grade Serous Ovarian Cancer
DescriptionInter-tumor heterogeneity is a reflective of the coalescence of a myriad of genomic, transcriptional, translational, and post-translational molecular features. To investigate the contribution of protein glycosylation in tumor heterogeneity in high-grade serous ovarian carcinoma (HGSC), we performed mass-spectrometry (MS)-based glycoproteomic characterization of 119 TCGA HGSC tissues. These HGSC tumor tissues have been previously characterized at the genomic and transcriptomic levels, as well as the proteomic and phosphoproteomic levels, by The Cancer Genomic Atlas (TCGA) consortia and the Clinical Proteomic Tumor Analysis Consortium (CPTAC), respectively. Employing two glycoproteomic strategies, Solid-Phase Extraction of Glycosite-containing peptides (SPEG) for glycosite analysis, and intact glycopeptides for investigation of glycosite-specific glycans (IGPs), we profiled the N-linked glycoproteome in HGSCs, identifying and quantifying glycosites and attached glycan structures.
HostingRepositoryMassIVE
AnnounceDate2020-06-20
AnnouncementXMLSubmission_2020-06-20_06:11:12.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportSupported dataset by repository
PrimarySubmitterJianbo Pan
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListdeglycosylated asparagine
InstrumentQ Exactive; Orbitrap Fusion Lumos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-06-19 21:40:19ID requested
12020-06-20 06:11:12announced
Publication List
no publication
Keyword List
submitter keyword: Glycoproteomics, Tumor heterogeneity, High-Grade Serous Ovarian Carcinoma (HGSC) , Glycosylation, Mass Spectrometry
Contact List
Hui Zhang
contact affiliationDepartment of Pathology, School of Medicine, Johns Hopkins University
contact emailhuizhang@jhu.edu
lab head
Jianbo Pan
contact affiliationJohns Hopkins University
contact emailpanjianbo87@gmail.com
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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