PXD019640

PXD019640 is an original dataset announced via ProteomeXchange.

Title	The pan-HER kinase inhibitor Neratinib modulates plant defense signaling by covalent targeting of an Arabidopsis epoxide hydrolase
Description	The goal of this project was to identify the target of the human covalent kinase inhibitor drug neratinib in Arabidopsis samples. To this end we applied activity-based protein profilling using the neratinib alkyne derivative.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:44:53.545.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Farnusch Kaschani
SpeciesList	scientific name: Arabidopsis thaliana (Mouse-ear cress); NCBI TaxID: 3702; scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	monohydroxylated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	LTQ Orbitrap Elite

Revision	Datetime	Status	ChangeLog Entry
0	2020-06-08 00:04:23	ID requested
1	2023-04-21 09:04:31	announced
⏵ 2	2024-10-22 05:44:53	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

submitter keyword: ABPP, Inhibitor, plant immunity,Neratinib, Kinase

Farnusch Kaschani
contact affiliation	Farnusch Kaschani, Analytics Core Facility Essen (ACE), Chemische Biologie, Universität Duisburg-Essen, ZMB, Germany
contact email	farnusch.kaschani@uni-due.de
lab head
Farnusch Kaschani
contact affiliation	University Duisburg-Essen
contact email	farnusch.kaschani@uni-due.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2023/04/PXD019640

PRIDE project URI

• PRIDE
  1. PXD019640
     1. Label: PRIDE project
     2. Name: The pan-HER kinase inhibitor Neratinib modulates plant defense signaling by covalent targeting of an Arabidopsis epoxide hydrolase