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PXD018995

PXD018995 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleSIRT3 interactions and mitochondrial proteome during HCMV infection
DescriptionSIRT3 has been shown to inhibit HCMV infection, but the mechanism under the antiviral effect is not clear. To identify the mediator of SIRT3 antiviral function, we aim to identify and quantify SIRT3 interactions during HCMV infection. A set of large-scale IPs were performed to determine the specific interactions with SIRT3 during infection, while small-scale IPs were conducted to determine the temporal interactions over the life cycle of infection. The mitochondrial proteome was used to characterize the changes of protein abundances after infection, and it was used for the normalization of acetylation.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_05:20:41.052.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterXinlei Sheng
SpeciesList scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationListcarbamoylated residue; phosphorylated residue; monohydroxylated residue; acetylated residue; deamidated residue
InstrumentQ Exactive HF; LTQ Orbitrap Velos
Dataset History
RevisionDatetimeStatusChangeLog Entry
02020-05-05 01:20:27ID requested
12021-04-01 13:47:58announced
22024-10-22 05:20:41announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: HCMV, mitochondrial proteome, IP-MS,SIRT3
Contact List
Ileana M. Cristea
contact affiliationDepartment of molecular biology, Princeton University, US
contact emailicristea@princeton.edu
lab head
Xinlei Sheng
contact affiliationPrinceton University
contact emailxsheng@princeton.edu
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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