PXD018865 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Mouse Muscle Stem Cell Proteome during Activation and CPEB1 Dependent Proteome in Mouse Muscle Stem Cell |
Description | Muscle Stem Cells or satellite cells (SCs) are required for muscle regeneration. In resting muscles, SCs are kept in quiescence. After injury, SCs undergo rapid activation, proliferation and differentiation to repair damaged muscles. The transcriptome alteration during SC activation is well characterized. While transcriptome is not exactly represent proteome because of post-transcriptional regulations such as miRNA induced gene silencing. However, little is known about SC proteome. We obtained quisecent SCs (QSCs) and freshly isolated SCs (fiSCs, early activated SCs) and activated SCs (ASCs) for high resolution mass spectrometry Bruker timsTOF Pro. Thus, we uncovered the QSC proteome. By comparison of QSC proteome to fiuSCs proteome or ASCs proteome, we identified the pathways that are differentially expressed between them. Forthermore, we characterized a translational regulator CPEB1 reprogrammed translation landscape for SC activation. |
HostingRepository | PRIDE |
AnnounceDate | 2021-11-05 |
AnnouncementXML | Submission_2021-11-05_04:07:18.831.xml |
DigitalObjectIdentifier | https://dx.doi.org/10.6019/PXD018865 |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Supported dataset by repository |
PrimarySubmitter | Tom Cheung |
SpeciesList | scientific name: Mus musculus (Mouse); NCBI TaxID: 10090; |
ModificationList | Phospho; Deamidated; Oxidation; Acetyl; Carbamidomethyl |
Instrument | timsTOF Pro |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-04-28 09:30:13 | ID requested | |
⏵ 1 | 2021-11-05 04:07:19 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Mouse, Muscle Stem Cell, CPEB1, Proteome, Activation |
Contact List
Tom. H. CHEUNG |
contact affiliation | Division of Life Science, Center for Stem Cell Research, Center of Systems Biology and Human Health, State Key Laboratory in Molecular Neuroscience, Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, HKUST Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, 518057, Shenzhen, Guangdong, China. |
contact email | tcheung@ust.hk |
lab head | |
Tom Cheung |
contact affiliation | Hong Kong University of Science and Technology |
contact email | tcheung@ust.hk |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/11/PXD018865 |
PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018865
- Label: PRIDE project
- Name: Mouse Muscle Stem Cell Proteome during Activation and CPEB1 Dependent Proteome in Mouse Muscle Stem Cell