PXD018848 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Systematic Analysis of the Lysine Crotonylome and multiple PTM analysis (acetylation, succinylation and crotonylation) in Candida albicans |
Description | LC-MS/MS was used to carry out the analysis of the crotonylome in C. albicans (Candida albicans) comprehensively in our study. Generally, 5242 specific crotonylated sites of 1584 crotonylated proteins were detected among 9038 proteins in C. albicans. The crotonylome involved in the regulation of metabolism through the bioinformatics analysis. Moreover, the crotonylated proteins related to biosynthesis and carbon metabolism were prevalence phenomenon. Moreover, a universal rule were found in crotonylated motifs: D/E were found in the position (+1, +2 or +3) and K/R were found in the position (+5 or +6) of the residue; A/E/F/G/P/W/Y were found in the -1 position and A/K/R were found in the position (-5, -6, -7 or -8) of the residue. As far as we know, crotonylated histone sites that screened in C. albicans of this study have not been reported before. Furthermore, a variety of connections in PPI (protein-protein interaction network) of ribosome, oxidative phosphorylation, nucleus and proteasome were modified by acetylation, succinylation and crotonylation. Sir2 inhibitor AK-1 was able to promote histone lysine crotonylation and non-histone lysine crotonylation. |
HostingRepository | PRIDE |
AnnounceDate | 2021-01-08 |
AnnouncementXML | Submission_2021-01-08_00:00:49.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | xiaowei zhou |
SpeciesList | scientific name: Candida albicans; NCBI TaxID: 5476; |
ModificationList | N6-crotonyl-L-lysine |
Instrument | Q Exactive HF-X |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2020-04-28 01:09:40 | ID requested | |
⏵ 1 | 2021-01-08 00:00:49 | announced | |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: C. albicans |
Crotonylome |
Histone |
Lysine crotonylation motif |
PPI |
Contact List
Xiaofang Li |
contact affiliation | Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing 210042, China |
contact email | zhouxw@pumcderm.cams.cn |
lab head | |
xiaowei zhou |
contact affiliation | Department of Medical Mycology, Institute of Dermatology, Chinese Academy of Medical Science and Peking Union Medical College; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs |
contact email | zhouxw@pumcderm.cams.cn |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD018848
- Label: PRIDE project
- Name: Systematic Analysis of the Lysine Crotonylome and multiple PTM analysis (acetylation, succinylation and crotonylation) in Candida albicans