PXD018781

PXD018781 is an original dataset announced via ProteomeXchange.

Title	Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites
Description	Apicomplexan parasites cause numerous diseases in humans and animals, including malaria (Plasmodium species) and toxoplasmosis (Toxoplasma gondii). Despite being a major drug target, the protein composition of the coenzyme Q:cytochrome c oxidoreductase complex (Complex III) in these parasites was previously unknown. Our work highlights the divergence of mitochondrial ETC Complex III composition in apicomplexan parasites and provides a broader understanding of Complex III evolution. Our study also provides important insights into what sets this major drug target apart from the equivalent complex in host species. Future studies can build on our findings to reveal how novel subunits contribute to Complex III function to further investigate this important drug target.
HostingRepository	PRIDE
AnnounceDate	2021-01-27
AnnouncementXML	Submission_2021-01-26_23:03:01.xml
DigitalObjectIdentifier	https://dx.doi.org/10.6019/PXD018781
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Pierre Faou
SpeciesList	scientific name: Toxoplasma gondii GAB3-2007-GAL-DOM9; NCBI TaxID: 1204162;
ModificationList	Carbamidomethyl; iodoacetamide derivatized residue
Instrument	Q Exactive HF

Revision	Datetime	Status	ChangeLog Entry
0	2020-04-24 01:28:05	ID requested
⏵ 1	2021-01-26 23:03:01	announced

Dataset with its publication pending

submitter keyword: Toxoplasma gondii, Apicomplexa, mitochondria, electron transport chain, coenzyme Q:cytochrome c oxidoreductase

Giel G. van Dooren
contact affiliation	Research School of Biology, Australian National University, Canberra, Australia
contact email	giel.vandooren@anu.edu.au
lab head
Pierre Faou
contact affiliation	La Trobe University
contact email	P.faou@latrobe.edu.au
dataset submitter

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PRIDE project URI

• PRIDE
  1. PXD018781
     1. Label: PRIDE project
     2. Name: Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex in Toxoplasma gondii parasites