PXD016855

PXD016855 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Cerebral organoids model neocortical development disrupted by 16p11.2 CNV in autism
Description	The 16p11.2 is the most common copy number variant (CNV) associated with Autism Spectrum Disorder (ASD). We used patient-derived cerebral organoids to investigate neurodevelopmental pathways dysregulated by dosage changes of 16p11.2 CNV. To investigate molecular dysregulation in DEL and DUP organoids, we carried out RNA sequencing and Tandem Mass Tag mass spectrometry (TMT-MS) on 1-month and 3-month organoids from the same samples. In proteomic analyses, we quantified a total of 6126 proteins in 1-month and 5481 proteins in 3-month organoids, with 13 and 11 proteins from within 16p11.2 CNV, respectively. Transcriptomic and proteomic profiling of organoids identifies the key drivers of functional effect by 16p11.2 CNV during neocortical development.
HostingRepository	MassIVE
AnnounceDate	2021-08-02
AnnouncementXML	Submission_2021-08-02_20:58:54.340.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Nam-Kyung Yu
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	S-carboxamidomethyl-L-cysteine; unknown modification
Instrument	Orbitrap Fusion

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-12-19 10:17:49	ID requested
⏵ 1	2021-08-02 20:58:54	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: TMT 10-plex, cerebral organoid, autism, 16p11.2 CNV

submitter keyword: TMT 10-plex, cerebral organoid, autism, 16p11.2 CNV

Contact List

Lilia Iakoucheva
contact affiliation	UCSD
contact email	lilyak@health.ucsd.edu
lab head
Nam-Kyung Yu
contact affiliation	Scripps Research
contact email	namkyung@scripps.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084727/