PXD015333

PXD015333 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	The anti-MRSA compound KCR inhibits protein synthesis in Staphylococcus aureus
Description	S aureus was treated in triplicate with 3-O-alpha-L-(2",3"-di-p-coumaroyl)rhamnoside (KCR), oxacillin or vehicle and quantitative proteomic analysis was carried out using isobaric tags and mass spectrometry. 1190 proteins were identified and 552 were affected by KCR (q<0.01). Ontology analysis identified 6 distinct translation-related categories that were affected by KCR (PIANO, 10% false-discovery rate) including structural constituent of ribosome, translation, rRNA binding, tRNA binding, tRNA processing and aminoacyl-tRNA ligase activity. Median fold changes (KCR vs Control) for small and large ribosomal components were 1.46 and 1.43 respectively.
HostingRepository	MassIVE
AnnounceDate	2022-07-12
AnnouncementXML	Submission_2022-07-12_12:31:32.276.xml
DigitalObjectIdentifier
ReviewLevel	Non peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Supported dataset by repository
PrimarySubmitter	Nick Carruthers
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	L-methionine sulfoxide; S-carboxamidomethyl-L-cysteine
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2019-09-05 07:56:50	ID requested
⏵ 1	2022-07-12 12:31:32	announced

Publication List

no publication

no publication

Keyword List

submitter keyword: methicillin-resistant, Staphylococcus aureus, 3-O-alpha-L-(2",3"-di-p-coumaroyl)rhamnoside, KCR, proteomics, isobaric tags, mechanism of action

submitter keyword: methicillin-resistant, Staphylococcus aureus, 3-O-alpha-L-(2",3"-di-p-coumaroyl)rhamnoside, KCR, proteomics, isobaric tags, mechanism of action

Contact List

Nicholas Carruthers
contact affiliation	Wayne State University
contact email	carruthers@wayne.edu
lab head
Nick Carruthers
contact affiliation	Wayne State U
contact email	carruthers@wayne.edu
dataset submitter

Full Dataset Link List

MassIVE dataset URI
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084282/

MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000084282/