PXD015165 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | Next-generation diagnostic biomarkers for vivax malaria |
Description | The global impact of Plasmodium vivax has been largely underestimated for several decades due to lower mortality rates compared to P. falciparum. However, in recent times, the parasite has become a serious threat to public health due to its ability to cause severe malaria with fatal outcomes. Its unique biology makes it resilient to control measures and poses a challenge to available diagnostic methods. Diagnosis by RDTs is further restricted due to inadequate P. vivax specific antigens for species identification. Therefore, there is an urgent need to develop tests that employ antigens unique to the parasite. This study represents the first in-depth proteomics analysis of human plasma and parasite isolates to identify P. vivax protein biomarkers that can be tested for use in RDTs while developing diagnostics for malaria. Here we report 39 P. vivax proteins in human plasma and 103 highly expressed P. vivax proteins from parasite isolates with high confidence. Interestingly, five proteins, found to be unique to P. vivax were detected in both sources, representing the best candidates for evaluation as diagnostic markers. Moreover, targeted proteomics assays were used to validate some of these proteins. This study represents the first step in the development of new diagnostic assays for P. vivax malaria. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:59:12.103.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Shalini Aggarwal |
SpeciesList | scientific name: Plasmodium vivax; NCBI TaxID: 5855; |
ModificationList | iodoacetamide derivatized residue |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2019-08-27 05:47:05 | ID requested | |
1 | 2020-01-30 06:43:15 | announced | |
⏵ 2 | 2024-10-22 04:59:12 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Malaria Host-Pathogen Interaction Center (MaHPIC) |
submitter keyword: Multiple Reaction Monitoring,Malaria, parasite, biomarker candidates, Q Exactive Orbitrap, mass spectrometry, diagnosis |
Contact List
Prof. Sanjeeva Srivastava |
contact affiliation | Indian Institute of Technology Bombay |
contact email | sanjeeva@iitb.ac.in |
lab head | |
Shalini Aggarwal |
contact affiliation | IIT Bombay |
contact email | shalini.a@iitb.ac.in |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2020/01/PXD015165 |
PRIDE project URI |
Repository Record List
[ + ]
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- PRIDE
- PXD015165
- Label: PRIDE project
- Name: Next-generation diagnostic biomarkers for vivax malaria