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PXD015165

PXD015165 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleNext-generation diagnostic biomarkers for vivax malaria
DescriptionThe global impact of Plasmodium vivax has been largely underestimated for several decades due to lower mortality rates compared to P. falciparum. However, in recent times, the parasite has become a serious threat to public health due to its ability to cause severe malaria with fatal outcomes. Its unique biology makes it resilient to control measures and poses a challenge to available diagnostic methods. Diagnosis by RDTs is further restricted due to inadequate P. vivax specific antigens for species identification. Therefore, there is an urgent need to develop tests that employ antigens unique to the parasite. This study represents the first in-depth proteomics analysis of human plasma and parasite isolates to identify P. vivax protein biomarkers that can be tested for use in RDTs while developing diagnostics for malaria. Here we report 39 P. vivax proteins in human plasma and 103 highly expressed P. vivax proteins from parasite isolates with high confidence. Interestingly, five proteins, found to be unique to P. vivax were detected in both sources, representing the best candidates for evaluation as diagnostic markers. Moreover, targeted proteomics assays were used to validate some of these proteins. This study represents the first step in the development of new diagnostic assays for P. vivax malaria.
HostingRepositoryPRIDE
AnnounceDate2024-10-22
AnnouncementXMLSubmission_2024-10-22_04:59:12.103.xml
DigitalObjectIdentifier
ReviewLevelPeer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterShalini Aggarwal
SpeciesList scientific name: Plasmodium vivax; NCBI TaxID: 5855;
ModificationListiodoacetamide derivatized residue
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02019-08-27 05:47:05ID requested
12020-01-30 06:43:15announced
22024-10-22 04:59:12announced2024-10-22: Updated project metadata.
Publication List
Dataset with its publication pending
Keyword List
ProteomeXchange project tag: Biology/Disease-Driven Human Proteome Project (B/D-HPP), Malaria Host-Pathogen Interaction Center (MaHPIC)
submitter keyword: Multiple Reaction Monitoring,Malaria, parasite, biomarker candidates, Q Exactive Orbitrap, mass spectrometry, diagnosis
Contact List
Prof. Sanjeeva Srivastava
contact affiliationIndian Institute of Technology Bombay
contact emailsanjeeva@iitb.ac.in
lab head
Shalini Aggarwal
contact affiliationIIT Bombay
contact emailshalini.a@iitb.ac.in
dataset submitter
Full Dataset Link List
Dataset FTP location
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PRIDE project URI
Repository Record List
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