PXD014791

PXD014791 is an original dataset announced via ProteomeXchange.

Title	Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity
Description	Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is an integral part of the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. A key aim of DToxS is to generate both proteomic and transcriptomic signatures that cab predict adverse effects, especially cardiotoxicity, of drugs approved by the Food and Drug Administration. Towards this goal, high throughput shot-gun proteomics experiments (308 cell line/drug combinations + 64 HeLa control lysates + 9 auxiliary treatment samples) have been conducted at the Center for Advanced Proteomics Research at Rutgers-New Jersey Medical School. The integrated proteomic and transcriptomic signatures have been used for computational network analysis to identify cellular signatures of cardiotoxicity that may predict drug-induced toxicity and possible mitigation of such toxicities by mixing different drugs. Both raw and processed proteomics data have been carefully controlled for quality and have been made publicly available via the PRoteomics IDEntifications (PRIDE) database. As such, this broad drug-stimulated proteomic dataset is valuable for the prediction drug toxicities and their mitigation.
HostingRepository	PRIDE
AnnounceDate	2021-10-28
AnnouncementXML	Submission_2021-10-28_08:21:41.142.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yuguang Xiong
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	dehydrated residue; acetylated residue; iodoacetamide derivatized residue
Instrument	Q Exactive

Revision	Datetime	Status	ChangeLog Entry
0	2019-07-29 01:37:53	ID requested
1	2019-10-11 07:52:57	announced
⏵ 2	2021-10-28 08:21:41	announced	2021-10-28: Updated project metadata.

Dataset with its publication pending

submitter keyword: cardiotoxicity, drug, signature,proteomics, mass spectrometry, kinase inhibitor

Hong Li [1] and Evren U. Azeloglu [2]
contact affiliation	Department of Biochemistry & Molecular Biology, New Jersey Medical School of Rutgers University [1] Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai [2]
contact email	liho2@njms.rutgers.edu
lab head
Yuguang Xiong
contact affiliation	Icahn School of Medicine at Mount Sinai
contact email	yuguang.xiong@mssm.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2021/10/PXD014791

PRIDE project URI

• PRIDE
  1. PXD014791
     1. Label: PRIDE project
     2. Name: Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity