PXD012542
PXD012542 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Proteome profiling of triple negative breast cancer cells overexpressing NOD1 and NOD2 receptors unveils molecular signatures of malignant cell proliferation |
Description | Triple negative breast cancer (TNBC) is a malignancy with very poor prognosis, due to its aggressive clinical characteristics and lack of response to receptor-targeted drug therapy. In TNBC, immune-related pathways are typically upregulated and may be associated with a better prognosis of the disease, encouraging the pursuit for immunotherapeutic options. A number of immune-related molecules have already been associated to the onset and progression of breast cancer, including NOD1 and NOD2, innate immune receptors of bacterial-derived components which activate pro-inflammatory and survival pathways. In the context of TNBC, overexpression of either NOD1 or NOD2 is shown to reduce cell proliferation and increase the in vitro clonogenic potential. To further investigate the pathways linking NOD1 and NOD2 signaling to tumorigenesis in TNBC, here, we undertook a global proteome profiling of TNBC-derived cells ectopically expressing each one of these NOD receptors |
HostingRepository | MassIVE |
AnnounceDate | 2019-02-11 |
AnnouncementXML | Submission_2019-02-11_14:07:40.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Alexandre Rosa Campos |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | Oxidation; Acetyl |
Instrument | Orbitrap Fusion ETD |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2019-01-28 23:47:17 | ID requested | |
⏵ 1 | 2019-02-11 14:07:40 | announced |
Publication List
no publication |
Keyword List
submitter keyword: Triple negative breast cancer, NOD1, NOD2 |
Contact List
Ricardo G. Correa | |
---|---|
contact affiliation | SBP Medical Discovery Institute |
contact email | rcorrea@sbpdiscovery.org |
lab head | |
Alexandre Rosa Campos | |
contact affiliation | SBP Medical Discovery Institute |
contact email | arosacampos@sbpdiscovery.org |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000083373 |