PXD011209

PXD011209 is an original dataset announced via ProteomeXchange.

Title	Two of a kind: Transmissible Schwann cell cancers in the endangered Tasmanian devil.
Description	Devil facial tumour disease 1 and 2 (DFT1 and DFT2) are two genetically distinct transmissible cancers endangering the survival of the Tasmanian devil (Sarcophilus harrisii). DFT1 first arose from a cell of the Schwann cell lineage, however, the tissue-of-origin of the recently discovered DFT2 cancer remains unknown. Here we have performed mRNA and protein expression analyses to show that variation in expression patterns between DFT1 and DFT2 tumours is low. Furthermore, DFT2 cells express a range of markers associated with Schwann cell differentiation, suggesting a similar tissue-of-origin to DFT1 tumours. These findings suggest that devils may be predisposed to transmissible cancers of Schwann cell origin. The emergence of these two unique cancers presents an unprecedented opportunity to gain insight into cancer development in animal species.
HostingRepository	PRIDE
AnnounceDate	2023-11-14
AnnouncementXML	Submission_2023-11-14_08:49:45.404.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Karthik Shantharam kamath
SpeciesList	scientific name: Sarcophilus harrisii; NCBI TaxID: 9305;
ModificationList	iodoacetamide derivatized residue
Instrument	TripleTOF 6600

Revision	Datetime	Status	ChangeLog Entry
0	2018-09-27 08:28:34	ID requested
1	2019-08-06 01:59:54	announced
⏵ 2	2023-11-14 08:49:45	announced	2023-11-14: Updated project metadata.

Dataset with its publication pending

submitter keyword: Tasmanian devil, SWATH, Devil facial tumour disease, Proteomics

Amanda L Patchett
contact affiliation	Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania 7000, Australia.
contact email	Amanda.Patchett@utas.edu.au
lab head
Karthik Shantharam kamath
contact affiliation	Macquarie university
contact email	karthikskamath@gmail.com
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2019/08/PXD011209

PRIDE project URI

• PRIDE
  1. PXD011209
     1. Label: PRIDE project
     2. Name: Two of a kind: Transmissible Schwann cell cancers in the endangered Tasmanian devil.