PXD009152

PXD009152 is an original dataset announced via ProteomeXchange.

Title	Phosphotyrosine profiling of human cerebrospinal fluid
Description	Cerebrospinal Fluid (CSF) surrounds the brain and provides it protection inside the skull. It is also used clinically for diagnosis of neurological disorders as well as to monitor disease progression. Neurodegeneration in the brain is known to be associated with altered phosphorylation of proteins expressed in the brain. Most studies have focused on serine/threonine phosphorylation although identification of abnormally tyrosine phosphorylated proteins in CSF can similarly reveal additional biomarkers for neurodegenerative diseases. To achieve this goal, we carried out phosphotyrosine profiling of CSF using phosphotyrosine antibody-based enrichment and high resolution mass spectrometry.
HostingRepository	PRIDE
AnnounceDate	2024-10-22
AnnouncementXML	Submission_2024-10-22_05:33:33.117.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Akhilesh Pandey
SpeciesList	scientific name: Homo sapiens (Human); NCBI TaxID: 9606;
ModificationList	phosphorylated residue
Instrument	Orbitrap Fusion Lumos

Revision	Datetime	Status	ChangeLog Entry
0	2018-03-09 01:38:19	ID requested
1	2022-02-23 08:58:43	announced
⏵ 2	2024-10-22 05:33:33	announced	2024-10-22: Updated project metadata.

Dataset with its publication pending

curator keyword: Biological, Biomedical

submitter keyword: brain, CSF,Cerebrospinal fluid, phosphotyrosine

Akhilesh Pandey
contact affiliation	733 N. Broadway Miller Research Building room 527 Johns Hopkins University Baltimore, MD 21205
contact email	pandey@jhmi.edu
lab head
Akhilesh Pandey
contact affiliation	Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905
contact email	pandey.akhilesh@mayo.edu
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD009152

PRIDE project URI

• PRIDE
  1. PXD009152
     1. Label: PRIDE project
     2. Name: Phosphotyrosine profiling of human cerebrospinal fluid