PXD006452 is an
original dataset announced via ProteomeXchange.
Dataset Summary
Title | CDK5 and GSK3 mediate neuroinflammation-induced neurodegeneration |
Description | Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive paralysis resulting from specific degeneration of upper and lower motor neurons (MNs). Chronic neuroinflammation, mediated by activated microglia, is a hallmark of patients diagnosed with ALS, and correlates with disease pathogenesis. Protecting MNs, particularly from toxic insults caused by neuroinflammation, could lead to effective treatments of ALS patient. Here, we report a screening campaign identifying a series of pyrazolotriazines that cell-autonomously protect MNs against neuroinflammation. We demonstrate that these compounds inhibit Cyclin-dependent kinase 5 (CDK5) and Glycogen synthase kinase 3 (GSK3), and we use phospho-proteomics to show that neuroprotection is linked to alterations in microtubule dynamics. |
HostingRepository | PRIDE |
AnnounceDate | 2024-10-22 |
AnnouncementXML | Submission_2024-10-22_04:37:02.676.xml |
DigitalObjectIdentifier | |
ReviewLevel | Peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Hannes Drexler |
SpeciesList | scientific name: Homo sapiens (Human); NCBI TaxID: 9606; |
ModificationList | phosphorylated residue; monohydroxylated residue; acetylated residue |
Instrument | LTQ Orbitrap Velos |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
0 | 2017-05-04 23:48:46 | ID requested | |
1 | 2019-01-30 04:00:37 | announced | |
⏵ 2 | 2024-10-22 04:37:03 | announced | 2024-10-22: Updated project metadata. |
Publication List
Dataset with its publication pending |
Keyword List
curator keyword: Biomedical |
submitter keyword: LC-MSMS, neuroinflammation,Amyotrophic lateral sclerosis, pyrazolotriazines, phosphoproteomics, motoneuron |
Contact List
Hannes C. A. Drexler |
contact affiliation | Bioanalytical Mass Spectrometry, Max Planck Institute for Molecular Biomedicine, Roentgenstr. 20, 48149 Muenster, Germany |
contact email | hannes.drexler@mpi-muenster.mpg.de |
lab head | |
Hannes Drexler |
contact affiliation | Bioanalytical Mass Spectrometry, Max Planck Insitute for Molecular Biomedicine, Roentgenstr. 20, 48149 Münster, Germany |
contact email | hannes.drexler@mpi-muenster.mpg.de |
dataset submitter | |
Full Dataset Link List
Dataset FTP location
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PRIDE project URI |
Repository Record List
[ + ]
[ - ]
- PRIDE
- PXD006452
- Label: PRIDE project
- Name: CDK5 and GSK3 mediate neuroinflammation-induced neurodegeneration