PXD006357
PXD006357 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Cerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children |
Description | Clinically distinguishing acute bacterial meningitis from cerebral malaria, both of which are important causes of acute non-traumatic coma associated with morbidity and mortality among paediatric hospital admissions in malaria endemic areas of Africa, is challenging. Few hospitals have diagnostic capacity for distinguishing the two syndromes resulting in broader antibiotic cover than necessary. A biochemical marker of ABM would facilitate precise clinical diagnosis and management of these infections. In this study, we used Label-free protein quantification by mass spectrometry to identify components of the CSF protein expression profiles of children with ABM that distinguish from those with CM with a high degree of specificity and sensitivity and that could be developed into point-of-care tests. James M. Njunge, Ian N. Oyaro, Nelson K. Kibinge, Martin K. Rono, Symon Kariuki, Charles R. Newton, James A. Berkley, Evelyn Gitau |
HostingRepository | MassIVE |
AnnounceDate | 2017-04-24 |
AnnouncementXML | Submission_2017-04-24_03:02:50.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | James Njunge |
SpeciesList | scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606; |
ModificationList | N-acetylated residue; Carbamidomethyl |
Instrument | Q Exactive |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2017-04-24 01:23:25 | ID requested | |
⏵ 1 | 2017-04-24 03:02:51 | announced |
Publication List
Dataset with its publication pending |
Keyword List
submitter keyword: Biomarkers, Acute Bacterial Meningitis, Cerebral Malaria, Cerebrospinal Fluid, proteomics, Q Exactive, Label Free Quantification |
Contact List
James M. Njunge | |
---|---|
contact affiliation | KEMRI-Wellcome.org |
contact email | jnjunge@kemri-wellcome.org |
lab head | |
James Njunge | |
contact affiliation | KEMRI Wellcome Trust Programme |
contact email | jnjunge@kemri-wellcome.org |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080979 |