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PXD006357

PXD006357 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleCerebrospinal fluid markers to distinguish bacterial meningitis from cerebral malaria in children
DescriptionClinically distinguishing acute bacterial meningitis from cerebral malaria, both of which are important causes of acute non-traumatic coma associated with morbidity and mortality among paediatric hospital admissions in malaria endemic areas of Africa, is challenging. Few hospitals have diagnostic capacity for distinguishing the two syndromes resulting in broader antibiotic cover than necessary. A biochemical marker of ABM would facilitate precise clinical diagnosis and management of these infections. In this study, we used Label-free protein quantification by mass spectrometry to identify components of the CSF protein expression profiles of children with ABM that distinguish from those with CM with a high degree of specificity and sensitivity and that could be developed into point-of-care tests. James M. Njunge, Ian N. Oyaro, Nelson K. Kibinge, Martin K. Rono, Symon Kariuki, Charles R. Newton, James A. Berkley, Evelyn Gitau
HostingRepositoryMassIVE
AnnounceDate2017-04-24
AnnouncementXMLSubmission_2017-04-24_03:02:50.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterJames Njunge
SpeciesList scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationListN-acetylated residue; Carbamidomethyl
InstrumentQ Exactive
Dataset History
RevisionDatetimeStatusChangeLog Entry
02017-04-24 01:23:25ID requested
12017-04-24 03:02:51announced
Publication List
Dataset with its publication pending
Keyword List
submitter keyword: Biomarkers, Acute Bacterial Meningitis, Cerebral Malaria, Cerebrospinal Fluid, proteomics, Q Exactive, Label Free Quantification
Contact List
James M. Njunge
contact affiliationKEMRI-Wellcome.org
contact emailjnjunge@kemri-wellcome.org
lab head
James Njunge
contact affiliationKEMRI Wellcome Trust Programme
contact emailjnjunge@kemri-wellcome.org
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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