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PXD005595

PXD005595 is an original dataset announced via ProteomeXchange.

Dataset Summary
TitleAlzheimer's disease proteomics
DescriptionThis project aims to determine how the brain proteome is remodeled in Alzheimer's disease (AD). AD is pathologically characterized by an accumulation of insoluble aggregates composed of Abeta peptides in the brain and is clinically characterized by progressive memory impairment. While the precise pathogenic mechanism(s) that drive AD remain unclear, synapse loss is a pathological hallmark and correlates with cognitive decline. Abeta peptides accumulate due in large part to perturbed protein degradation pathways, and increasing evidence shows that Abeta peptides impair multiple cellular pathways. To advance our understanding of these complex processes we have completed a comprehensive proteomic characterization of the three different AD mouse models before and after the onset of pathology.
HostingRepositoryMassIVE
AnnounceDate2017-10-23
AnnouncementXMLSubmission_2017-10-23_09:11:14.xml
DigitalObjectIdentifier
ReviewLevelNon peer-reviewed dataset
DatasetOriginOriginal dataset
RepositorySupportUnsupported dataset by repository
PrimarySubmitterSalvador Martínez de Bartolomé
SpeciesList scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090;
ModificationListS-carboxamidomethyl-L-cysteine
InstrumentLTQ Orbitrap Velos; LTQ Orbitrap Elite; Orbitrap Fusion
Dataset History
RevisionDatetimeStatusChangeLog Entry
02016-12-19 14:22:33ID requested
12017-10-23 09:11:15announced
Publication List
no publication
Keyword List
submitter keyword: Alzheimer's disease, quantitative proteomics, proteostasis, amyloid, synapses
Contact List
Jeffrey N. Savas, PhD
contact affiliationDepartment of Neurology Northwestern University
contact emailjeffrey.savas@northwestern.edu
lab head
Salvador Martínez de Bartolomé
contact affiliationThe Scripps Research Institute
contact emailsalvador@scripps.edu
dataset submitter
Full Dataset Link List
MassIVE dataset URI
Dataset FTP location
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