PXD005595
PXD005595 is an original dataset announced via ProteomeXchange.
Dataset Summary
Title | Alzheimer's disease proteomics |
Description | This project aims to determine how the brain proteome is remodeled in Alzheimer's disease (AD). AD is pathologically characterized by an accumulation of insoluble aggregates composed of Abeta peptides in the brain and is clinically characterized by progressive memory impairment. While the precise pathogenic mechanism(s) that drive AD remain unclear, synapse loss is a pathological hallmark and correlates with cognitive decline. Abeta peptides accumulate due in large part to perturbed protein degradation pathways, and increasing evidence shows that Abeta peptides impair multiple cellular pathways. To advance our understanding of these complex processes we have completed a comprehensive proteomic characterization of the three different AD mouse models before and after the onset of pathology. |
HostingRepository | MassIVE |
AnnounceDate | 2017-10-23 |
AnnouncementXML | Submission_2017-10-23_09:11:14.xml |
DigitalObjectIdentifier | |
ReviewLevel | Non peer-reviewed dataset |
DatasetOrigin | Original dataset |
RepositorySupport | Unsupported dataset by repository |
PrimarySubmitter | Salvador Martínez de Bartolomé |
SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
ModificationList | S-carboxamidomethyl-L-cysteine |
Instrument | LTQ Orbitrap Velos; LTQ Orbitrap Elite; Orbitrap Fusion |
Dataset History
Revision | Datetime | Status | ChangeLog Entry |
---|---|---|---|
0 | 2016-12-19 14:22:33 | ID requested | |
⏵ 1 | 2017-10-23 09:11:15 | announced |
Publication List
no publication |
Keyword List
submitter keyword: Alzheimer's disease, quantitative proteomics, proteostasis, amyloid, synapses |
Contact List
Jeffrey N. Savas, PhD | |
---|---|
contact affiliation | Department of Neurology Northwestern University |
contact email | jeffrey.savas@northwestern.edu |
lab head | |
Salvador Martínez de Bartolomé | |
contact affiliation | The Scripps Research Institute |
contact email | salvador@scripps.edu |
dataset submitter |
Full Dataset Link List
MassIVE dataset URI |
Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000080431 |