PXD004570

PXD004570 is an original dataset announced via ProteomeXchange.

Dataset Summary

Title	Proteome analyses of two ovarian clear cell carcinoma cell lines with or without ARID1A manipulation
Description	ARID1A, which encodes a component of the SWI/SNF chromatin-remodeling complex, is commonly mutated in ovarian clear cell carcinoma and many other cancer types. We used label-free LC-MS/MS to identify ARID1A-dependent proteome changes in ovarian clear cell carcinoma cell lines. In our first analysis, we compared ARID1A-wildtype ovarian clear cell carcinoma cell line OVCA429 with or without ARID1A CRISPR knockout. In a complementary analysis, we compared ARID1A-mutated ovarian clear cell carcinoma cell line OVISE with or without ARID1A overexpression using a tet-inducible promoter.
HostingRepository	MassIVE
AnnounceDate	2016-09-21
AnnouncementXML	Submission_2016-09-21_09:55:52.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Aaron Goldman
SpeciesList	scientific name: Homo sapiens; common name: human; NCBI TaxID: 9606;
ModificationList	Acetyl; Oxidation; Carbamidomethyl
Instrument	Q Exactive

Dataset History

Revision	Datetime	Status	ChangeLog Entry
0	2016-07-13 05:35:15	ID requested
⏵ 1	2016-09-21 09:55:52	announced

Publication List

Aaron R. Goldman, Benjamin G. Bitler, Zachary Schug, Jose R. Conejo-Garcia, Rugang Zhang, and David W. Speicher. The Primary Effect on the Proteome of ARID1A-Mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-Transcriptional Level. Mol Cell Proteomics mcp.M116.062539. First Published on September 21, 2016, doi:10.1074/mcp.M116.062539.

Aaron R. Goldman, Benjamin G. Bitler, Zachary Schug, Jose R. Conejo-Garcia, Rugang Zhang, and David W. Speicher. The Primary Effect on the Proteome of ARID1A-Mutated Ovarian Clear Cell Carcinoma is Downregulation of the Mevalonate Pathway at the Post-Transcriptional Level. Mol Cell Proteomics mcp.M116.062539. First Published on September 21, 2016, doi:10.1074/mcp.M116.062539.

Keyword List

submitter keyword: Ovarian clear cell carcinoma, ARID1A, BAF250a, SWI/SNF chromatin-remodeling complex, Ovarian cancer, Cancer, Human, LC-MS/MS, Epithelial ovarian cancer, Label-free quantitation, OVCA429, OVISE

submitter keyword: Ovarian clear cell carcinoma, ARID1A, BAF250a, SWI/SNF chromatin-remodeling complex, Ovarian cancer, Cancer, Human, LC-MS/MS, Epithelial ovarian cancer, Label-free quantitation, OVCA429, OVISE

Contact List

David W. Speicher
lab head
Aaron Goldman
contact affiliation	The Wistar Institute
contact email	agoldman@wistar.org
dataset submitter

Full Dataset Link List

MassIVE dataset URI
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MassIVE dataset URI

Dataset FTP location
NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive.ucsd.edu/MSV000079904