PXD002288

PXD002288 is an original dataset announced via ProteomeXchange.

Title	PTSD mouse amygdala proteome .
Description	Posttraumatic stress disorder (PTSD) is a prevalent psychiatric disorder. Several studies have attempted to characterize molecular alterations associated with PTSD, but most findings were limited to the investigation of specific cellular markers in the periphery or defined brain regions. In the current study, we aimed to unravel affected molecular pathways/mechanisms in the fear circuitry associated with PTSD. We interrogated a foot shock induced-PTSD mouse model by integrating proteomics and metabolomics profiling data. Alterations at the proteome level were analyzed using in vivo 15N metabolic labeling combined with mass spectrometry in prelimbic cortex (PrL), anterior cingulate cortex (ACC), basolateral amygdala (BLA), central nucleus of amygdala (CeA) and CA1 of hippocampus between shocked and non-shocked (control) mice, with and without fluoxetine treatment.
HostingRepository	PRIDE
AnnounceDate	2024-10-03
AnnouncementXML	Submission_2024-10-03_07:59:36.810.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Chi-Ya Kao
SpeciesList	scientific name: Mus musculus (Mouse); NCBI TaxID: 10090;
ModificationList	iodoacetamide derivatized residue
Instrument	LTQ Orbitrap

Revision	Datetime	Status	ChangeLog Entry
0	2015-06-02 04:34:19	ID requested
⏵ 1	2024-10-03 07:59:37	announced

Dataset with its publication pending

curator keyword: Biological

submitter keyword: PTSD, LC-MSMS, brain, mouse

Christoph W Turck
contact affiliation	Department of Translational Research in Psychiatry Max Planck Institute of Psychiatry, Munich
contact email	turck@psych.mpg.de
lab head
Chi-Ya Kao
contact affiliation	Max Planck Institute of Psychiatry
contact email	chi-ya_kao@psych.mpg.de
dataset submitter

Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://ftp.pride.ebi.ac.uk/pride/data/archive/2022/02/PXD002288

PRIDE project URI

• PRIDE
  1. PXD002288
     1. Label: PRIDE project
     2. Name: PTSD mouse amygdala proteome