⮝ Full datasets listing
PXD083965
PXD083965 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Biomimetic ROS-Responsive Prodrug Nanoparticles Regulating Mitochondrial and Immune Homeostasis for Renal Fibrosis Therapy |
| Description | This dataset contains LC-MS/MS proteomic data of hybrid biomimetic nanoparticles (MPA NPs) and their source membrane materials, including platelet membrane (PM) and M1 macrophage membrane (MM). MPA NPs are ROS-responsive prodrug nanoparticles coated with fused platelet/M1 macrophage hybrid cell membrane, constructed for targeted therapy of renal fibrosis. The proteomic analysis was performed to characterize the protein composition retained on the hybrid membrane-coated nanoparticles, verifying successful membrane fusion and membrane protein preservation after nanoparticle fabrication. All samples were digested by trypsin and analyzed using Q-Exactive Orbitrap mass spectrometer. Raw mass spectrometry data were searched against the *Mus musculus* UniProt reference database with FDR < 1%. This proteomic dataset reveals the membrane protein profile of MPA NPs, supporting the mechanism that hybrid membrane endows nanoparticles with immune escape and injured kidney targeting capacity. |
| HostingRepository | iProX |
| AnnounceDate | 2026-09-09 |
| AnnouncementXML | Submission_2026-09-10_02:12:53.418.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yaheng Wang |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-09-10 02:12:05 | ID requested | |
| ⏵ 1 | 2026-09-10 02:12:53 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Renal fibrosis, Biomimetic nanoparticles, ROS‑responsive prodrug, Inflammation, Mitochondria |
Contact List
| Xiaowen Yu | |
|---|---|
| contact affiliation | Anhui Medical University |
| contact email | yuxiaowen@ahmu.edu.cn |
| lab head | |
| Yaheng Wang | |
| contact affiliation | Anhui Medical University |
| contact email | i2545011013@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
