PXD083928

PXD083928 is an original dataset announced via ProteomeXchange.

Title	Quantitative exoproteomic profiling reveals the regulatory role of Fur in Staphylococcus aureus virulence factor expression
Description	This dataset contains extracellular proteomic profiling (exoproteome) of Staphylococcus aureus strain Newman wild-type (WT/pYJ335), fur deletion mutant (Δfur/pYJ335), and fur-complemented strain (Δfur/p-fur) cultured in RPMI plus 1% casamino acids (CA) for 9 h. Proteins in culture supernatants were precipitated with 10% TCA, digested with trypsin, and analyzed via DIA-MS (dia-PASEF mode) on an EvoSep One coupled with a timsTOF Pro mass spectrometer. The study investigates the direct and indirect transcriptional and post-transcriptional regulatory impact of Fur on S. aureus exoprotein expression.
HostingRepository	iProX
AnnounceDate	2026-09-09
AnnouncementXML	Submission_2026-09-09_18:24:11.036.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Feifei Chen
SpeciesList	scientific name: Staphylococcus aureus; NCBI TaxID: 1280;
ModificationList	No PTMs are included in the dataset
Instrument	timsTOF Pro

Revision	Datetime	Status	ChangeLog Entry
0	2026-09-09 18:23:41	ID requested
⏵ 1	2026-09-09 18:24:11	announced

Dataset with its publication pending

submitter keyword: Staphylococcus aureus, Fur, exoproteome, hla, dia-PASEF, iron homeostasis

Lefu Lan
contact affiliation	School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
contact email	llan@ucas.ac.cn
lab head
Feifei Chen
contact affiliation	Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences
contact email	feifei2004555@126.com
dataset submitter

iProX dataset URI