PXD083912

PXD083912 is an original dataset announced via ProteomeXchange.

Title	The Kaempferol-Fe Assembled Nanomedicine Delivery System Alleviates Intervertebral Disc Degeneration Through Metabolic-Immune Regulation
Description	This project contains DIA LC‑MS/MS proteomic profiling of nucleus pulposus tissues from 16 human patients with intervertebral disc degeneration (IDD) (6 Pfirrmann grade II, 10 grade V) to identify molecular changes associated with IDD progression. A total of 2,215 unique proteins were detected, 941 proteins met the within‑group missing‑rate filter (<50%) as high‑confidence identifications, and 194 proteins were differentially expressed between grade V and grade II (96 upregulated, 98 downregulated; |ratio|>1.2, p<0.05). Results highlight metabolic–immune pathway dysregulation in advanced IDD and supported downstream functional validation.
HostingRepository	iProX
AnnounceDate	2026-09-08
AnnouncementXML	Submission_2026-09-09_17:55:18.602.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Ziyue Zhou
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606;
ModificationList	No PTMs are included in the dataset
Instrument	ZenoTOF 7600

Revision	Datetime	Status	ChangeLog Entry
0	2026-09-09 17:54:46	ID requested
⏵ 1	2026-09-09 17:55:19	announced

Dataset with its publication pending

submitter keyword: Intervertebral disc degeneration, Kaempferol, Metal-phenolic network, Hydrogel, Metabolic-immune regulation, Nanomedicine

Lei Fang
contact affiliation	Nanjing University
contact email	njfanglei@nju.edu.cn
lab head
Ziyue Zhou
contact affiliation	Nanjing University
contact email	602024350025@smail.nju.edu.cn
dataset submitter

iProX dataset URI