⮝ Full datasets listing
PXD083793
PXD083793 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Albendazole induces ferroptosis through the USP7-GPX4 axis in B-cell acute lymphoblastic leukemia |
| Description | B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological malignancy that still requires the development of novel therapeutic strategies. Here, leveraging a drug-repurposing strategy, we performed a high-throughput screen of 3,008 U.S. Food and Drug Administration (FDA)-approved drugs and identified albendazole (ABZ), a benzimidazole anthelmintic, as a potent agent against B-ALL across multiple preclinical models. Mechanistically, ABZ directly binds ubiquitin-specific protease 7 (USP7) and triggers its autophagy-dependent destabilization, subsequently promoting the ubiquitin-proteasome-mediated degradation of glutathione peroxidase 4 (GPX4), thereby inducing ferroptosis in B-ALL. Our study revealed that USP7 directly interacts with and stabilizes GPX4 by removing K48-linked ubiquitin chains, and both proteins are markedly upregulated in B-ALL patients, correlating with poor survival. Collectively, we identify a previously unrecognized USP7-GPX4 axis that governs ferroptosis and show that ABZ, as a novel ferroptosis inducer, triggers ferroptosis by targeting this axis, supporting clinical repurposing of albendazole or therapeutic targeting of USP7-GPX4 to improve B-ALL outcomes. |
| HostingRepository | iProX |
| AnnounceDate | 2026-09-07 |
| AnnouncementXML | Submission_2026-09-07_02:06:32.695.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Hao Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-09-07 02:05:42 | ID requested | |
| ⏵ 1 | 2026-09-07 02:06:33 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Albendazole,USP7,GPX4,ferroptosis |
Contact List
| Yuhua Li | |
|---|---|
| contact affiliation | Zhujiang Hospital, Southern Medical University |
| contact email | liyuhua1974@outlook.com |
| lab head | |
| Hao Wang | |
| contact affiliation | Zhujiang Hospital, Southern Medical University |
| contact email | wh2372100348@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
