PXD083324

PXD083324 is an original dataset announced via ProteomeXchange.

Title	Integrated multi-omics reveals phosphorylation-dependent lysosomal dysfunction underlying proteostasis failure during skeletal muscle aging
Description	Through integrative multi-omics profiling of human skeletal muscle, non-human primate skeletal muscle, and human skeletal muscle cell lines, we characterized the conserved protein accumulation and lysosomal remodeling signatures associated with skeletal muscle aging using proteomics, phosphoproteomics, and ubiquitinomics datasets. The human and primate tissue data were employed to define common aging phenotypes, while the cellular proteomic and phosphoproteomic data were further utilized to dissect the underlying molecular mechanisms. Together, this multi-omics dataset provides a systematic foundation for identifying key pathways and regulatory nodes in skeletal muscle aging.
HostingRepository	iProX
AnnounceDate	2026-08-28
AnnouncementXML	Submission_2026-08-28_00:11:03.586.xml
DigitalObjectIdentifier
ReviewLevel	Peer-reviewed dataset
DatasetOrigin	Original dataset
RepositorySupport	Unsupported dataset by repository
PrimarySubmitter	Yu Liu
SpeciesList	scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Macaca mulatta; NCBI TaxID: 9544; scientific name: Trichuris sp. ex Macaca fascicularis JP-2011; NCBI TaxID: 1035826; scientific name: Mus musculus; NCBI TaxID: 10090;
ModificationList	ubiquitination signature dipeptidyl lysine
Instrument	Q Exactive HF-X; Q Exactive Plus

Revision	Datetime	Status	ChangeLog Entry
0	2026-08-28 00:10:19	ID requested
⏵ 1	2026-08-28 00:11:04	announced

Dataset with its publication pending

submitter keyword: Proteomics, phosphoproteomics, ubiquitinomics

Lunzhi Dai
contact affiliation	Sichuan University
contact email	lunzhi.dai@scu.edu.cn
lab head
Yu Liu
contact affiliation	Sichuan University
contact email	yuliu_001@163.com
dataset submitter

iProX dataset URI