⮝ Full datasets listing
PXD083263
PXD083263 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | PI3K(p110alpha) Atrial Fibrosis and Heart |
| Description | Reduced phosphoinositide 3-Kinase [PI3K(p110alpha)] in the heart is associated with various cardiac diseases. Extracellular vesicles (EVs) are essential for maintaining normal cardiac function. However, their composition can be altered in pathological conditions, contributing to the progression of cardiovascular pathology. The aim of this study was to examine protein expression, signalling mechanisms, and potential sex-dependent differences from varying degrees of reduced PI3K(p110alpha) activity in the heart. Quantitative proteomics was performed on cardiac-derived EVs from female and male dnPI3K (cardiomyocyte-specific dominant-negative PI3K on a FVBN background: heterozygote dnPI3K (one dnPI3K transgene) and homozygote dnPI3K (two dnPI3K transgenes)) mice aged ~12 weeks. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-08-27 |
| AnnouncementXML | Submission_2026-08-27_16:49:00.785.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | David Greening |
| SpeciesList | scientific name: Mus musculus; common name: house mouse; NCBI TaxID: 10090; |
| ModificationList | Acetyl |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-26 23:18:57 | ID requested | |
| ⏵ 1 | 2026-08-27 16:49:01 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: heart, Atrial Fibrosis, PI3K, Extracellular vesicles, DatasetType:Proteomics |
Contact List
| David Greening | |
|---|---|
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| lab head | |
| David Greening | |
| contact affiliation | Baker Heart & Diabetes Institute |
| contact email | david.greening@baker.edu.au |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v14/MSV000103027/ |
