⮝ Full datasets listing
PXD083192
PXD083192 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Nogo-B Enhances the Inflammatory Microenvironment of Epicardial Adipose Tissue and Induces Atrial Fibrillation |
| Description | This study demonstrates that Nogo-B promotes atrial fibrillation (AF) progression by reshaping the inflammatory microenvironment of epicardial adipose tissue (EAT). Integrated metabolomic and proteomic analyses revealed increased EAT whitening and elevated Nogo-B expression in AF patients. In vitro and in vivo experiments showed that Nogo-B drives preadipocyte differentiation into white-like adipocytes through the AKT2–GSK3β–β-catenin pathway, enhancing inflammation, atrial fibrosis, and arrhythmogenesis. Co-culture models further confirmed indirect adverse effects on cardiomyocytes and fibroblasts. Pharmacological activation of β-catenin signaling partially reversed these pathological changes, suggesting Nogo-B as a potential therapeutic target for AF. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-25 |
| AnnouncementXML | Submission_2026-08-25_23:47:12.085.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Yuanzhe Yang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-25 23:46:53 | ID requested | |
| ⏵ 1 | 2026-08-25 23:47:12 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Nogo-B, Epicardial adipose tissue, Atrial fibrillation, Adipocyte whitening, Inflammation, AKT2-GSK3β-β-catenin |
Contact List
| Minglong Chen | |
|---|---|
| contact affiliation | Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University,211166 Nanjing, Jiangsu, China |
| contact email | chenminglong@njmu.edu.cn |
| lab head | |
| Yuanzhe Yang | |
| contact affiliation | Division of Cardiology, The First Affiliated Hospital of Nanjing Medical University,211166 Nanjing, Jiangsu, China |
| contact email | 948548251@qq.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
