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PXD083179
PXD083179 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Temporal profiling of the host lung proteome during lethal influenza A virus infection by DIA-MS |
| Description | Influenza A virus (IAV) infection induces profound alterations in host protein expression that dictate viral pathogenesis and host immune outcomes. To systematically trace dynamic host protein alterations during acute infection, we conducted a quantitative proteomic study on lung tissues from female BALB/c mice (6~8weeks old, n = 5 per group) intranasally infected with 10*LD50 of a mouse-adapted H1N1 strain (mH1N1). Lung tissue samples were harvested across a time-course of infection (0, 1, 3, and 5 days post-infection [dpi]) and analyzed via Data-Independent Acquisition mass spectrometry (DIA-MS). Over 9,000 host proteins were quantified per sample group. Differential expression analysis identified significant time-dependent proteomic changes, highlighting robust activation of innate immune defense, cytokine-mediated signaling, and neutrophil activity alongside dynamic remodeling of cell structures and metabolic pathways. Overall, this study establishes a comprehensive temporal host proteome landscape during lethal IAV infection, providing critical molecular targets for understanding IAV pathogenesis and developing antiviral strategies. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-24 |
| AnnouncementXML | Submission_2026-08-25_18:41:29.277.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Kexin Li |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-25 18:41:08 | ID requested | |
| ⏵ 1 | 2026-08-25 18:41:29 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Influenza A virus, Host proteome, DIA-MS, Mouse lung Time-course proteomics, Label-free quantification, Innate immunity, H1N1 |
Contact List
| Shuofeng Yuan | |
|---|---|
| contact affiliation | The University of HongKong |
| contact email | yuansf@hku.hk |
| lab head | |
| Kexin Li | |
| contact affiliation | The University of HongKong |
| contact email | likexin0127@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
