⮝ Full datasets listing
PXD083175
PXD083175 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Abhd17a deficiency enhances Zdhhc7 autopalmitoylation to drive Cav1-Cd36 complex formation and hepatic steatosis in ApoE−/− mice |
| Description | Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent global health burden, yet the post-translational mechanisms governing hepatic lipid homeostasis remain incompletely defined. Here, we identify the depalmitoylase Abhd17a as a critical suppressor of hepatic steatosis through its regulation of the palmitoyl acyltransferase Zdhhc7. While Abhd17a deficiency alone does not induce overt pathology in wild-type mice, its genetic ablation in ApoE−/− mice markedly accelerates MASLD progression, characterized by enhanced steatosis, inflammation, fibrosis, and insulin resistance. Mechanistically, Abhd17a directly interacts with and depalmitoylates Zdhhc7 at evolutionarily conserved cysteine residues Cys160 and Cys166, whose autopalmitoylation is essential for Zdhhc7 Golgi retention and enzymatic activity. Loss of Abhd17a enhances Zdhhc7 autopalmitoylation, promoting CAV1 palmitoylation and the subsequent formation of a Cav1-Cd36 complex that augments hepatic lipid uptake without altering transcriptional programs. Thus, the Abhd17a-Zdhhc7-Cav1/Cd36 axis represents a critical post-translational checkpoint and a promising therapeutic target for MASLD. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-24 |
| AnnouncementXML | Submission_2026-08-25_18:35:28.435.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Binhui Zhou |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | palmitoylated residue |
| Instrument | Q Exactive HF |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-25 18:34:55 | ID requested | |
| ⏵ 1 | 2026-08-25 18:35:28 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ApoE, palmitoylation, Abhd17a, Zdhhc7, Cav1, Cd36, MASLD |
Contact List
| Binhui Zhou | |
|---|---|
| contact affiliation | Henan Medical University |
| contact email | zhoubinhui@126.com |
| lab head | |
| Binhui Zhou | |
| contact affiliation | Henan Medical University |
| contact email | zhoubinhui@126.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
