⮝ Full datasets listing
PXD083108
PXD083108 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | ILC2-intrinsic IL-33 promotes ILC2 activation and exacerbates allergic lung 1 inflammation sup |
| Description | Mass spectrometry-based proteomics serves as an invaluable tool for pinpointing critical biomarkers and elucidating cellular functions and regulatory pathways. However, the proteomic changes in ILC2s during activation remain unexplored. To characterize the dynamic proteomic profiles of lung-resident ILC2s under physiological and inflammatory conditions, we performed high-resolution liquid chromatography-tandem mass spectrometry (LC-MS/MS) to systematically compare the molecular signatures of FACS-purified pulmonary ILC2 populations (Live CD45+CD90.2+Lineage- ST2+) isolated from two experimental groups: 1) steady-state control mice and 2) papain-challenged mice exhibiting acute airway inflammation (Fig. 1a and Supplementary Fig. 1a). Papain-induced lung inflammation was chosen because papain is a classical protease allergen triggering the release of pro-inflammatory factors including IL-33 to develop ILC2-derived lung inflammation. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-25 |
| AnnouncementXML | Submission_2026-08-25_01:26:28.344.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Liming Sun |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | 6x(13)C,4x(15)N labeled L-arginine; 6x(13)C,2x(15)N labeled L-lysine |
| Instrument | Orbitrap Astral |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-25 01:25:19 | ID requested | |
| ⏵ 1 | 2026-08-25 01:26:28 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: ILC2, IL-33, allergic lung inflammation |
Contact List
| Rong Zeng | |
|---|---|
| contact affiliation | Shanghai Clinical Research and Trial Center |
| contact email | zengrong@shanghaitech.edu.cn |
| lab head | |
| Liming Sun | |
| contact affiliation | University of Chinese Academy of Sciences |
| contact email | sunlm@ucas.ac.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
