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PXD083014
PXD083014 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Complexome profiling of mitochondria in the myzozoan parasite of oysters, Perkinsus marinus |
| Description | Mitochondrial complexes, such as the mitochondrial electron transport chain (mETC), the F1Fo-ATP synthase, the mitochondrial ribosome and the Translocase of the Outer Membrane (TOM) complex are centrally important for mitochondrial function and cell survival. Recently, an unexpected diversity in the composition of these complexes across unicellular eukaryotic lineages, with the apicomplexan parasites featuring prominently, has been revealed. However, whether the observed enlarged and divergent mitochondrial complexes are conserved across the wider lineages has not been investigated. Here, using a complexome profiling proteomic approach, we have characterised the composition of the mitochondrial complexes of the myzozoan parasite of oysters, Perkinsus marinus. We show that it shares new components of ATP synthase and the mETC complexes that in the deadly apicomplexan Plasmodium and Toxoplasma were shown to be important for growth. Moreover, the Perkinsus mitoribosome possesses many of the divergent features recently discovered in apicomplexans, including members of the ApiAP2 family that until recently were all considered to be transcription factors. Our study reveals that the divergent subunit composition of mitochondrial complexes is an ancestral and highly conserved feature of Myzozoa. In this study complexome profiling was performed on two samples of mitochondrially-enriched material, and on whole-cell material. |
| HostingRepository | MassIVE |
| AnnounceDate | 2026-08-22 |
| AnnouncementXML | Submission_2026-08-22_10:57:17.925.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Non peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Andrew Maclean |
| SpeciesList | scientific name: Perkinsus marinus; NCBI TaxID: 31276; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Orbitrap Fusion |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-22 10:11:45 | ID requested | |
| ⏵ 1 | 2026-08-22 10:57:18 | announced |
Publication List
| no publication |
Keyword List
| submitter keyword: Perkinsus marinus, Complexome profiling, Mitochondrial complexes, Mitoribosome, mETC, TOM complex, ATP Synthase, DatasetType:Proteomics |
Contact List
| Lilach Sheiner | |
|---|---|
| contact affiliation | University of Glasgow |
| contact email | lilach.sheiner@glasgow.ac.uk |
| lab head | |
| Andrew Maclean | |
| contact affiliation | University of Edinburgh |
| contact email | andrew.maclean@ed.ac.uk |
| lab head | |
| Andrew Maclean | |
| contact affiliation | University of Edinburgh |
| contact email | andrew.maclean@ed.ac.uk |
| dataset submitter | |
Full Dataset Link List
| MassIVE dataset URI |
| Dataset FTP location NOTE: Most web browsers have now discontinued native support for FTP access within the browser window. But you can usually install another FTP app (we recommend FileZilla) and configure your browser to launch the external application when you click on this FTP link. Or otherwise, launch an app that supports FTP (like FileZilla) and use this address: ftp://massive-ftp.ucsd.edu/v14/MSV000102983/ |
