⮝ Full datasets listing
PXD082675
PXD082675 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Proteomic profiling of LIPUS-treated mice with obesity-associated hepatic steatosis |
| Description | Obesity-associated hepatic steatosis is an important hepatic manifestation of obesity-related metabolic dysfunction, characterized by excessive hepatic lipid accumulation and closely associated with metabolic disturbances and increased risk of liver injury. Low-intensity pulsed ultrasound (LIPUS) is a non-invasive physical stimulation modality that has shown potential regulatory effects on metabolic homeostasis and inflammatory responses. However, the effects of LIPUS on obesity-associated hepatic steatosis and the associated hepatic proteomic alterations remain insufficiently understood. In this study, a high-fat diet-induced obese mouse model was established, and liver tissues were collected after LIPUS intervention. A mass spectrometry-based 4D-HT DIA quantitative proteomic approach was applied to systematically characterize hepatic proteomic alterations following LIPUS treatment. This dataset provides molecular profiling resources for investigating hepatic responses to LIPUS intervention in obesity-associated hepatic steatosis and supports further exploration of the underlying biological mechanisms. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-14 |
| AnnouncementXML | Submission_2026-08-16_21:10:12.889.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Xuelian Yi |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-16 21:09:42 | ID requested | |
| ⏵ 1 | 2026-08-16 21:10:13 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Low-intensity pulsed ultrasound, obesity, liver, quantitative proteomics, lipid metabolism |
Contact List
| Chi Zhang | |
|---|---|
| contact affiliation | Southwest Medical University |
| contact email | chizhang0123@swmu.edu.cn |
| lab head | |
| Xuelian Yi | |
| contact affiliation | Southwest Medical University |
| contact email | 18398154824@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
