⮝ Full datasets listing
PXD082433
PXD082433 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Photosynthetic bioenergetic-redox restoration rejuvenates the aged muscle regenerative niche |
| Description | Aging impairs skeletal muscle regeneration, but the physiological constraint that prevents effective repair remains unclear. Here we show that aged injured muscle fails to restore mitochondrial respiration, membrane potential, ATP/NADPH-associated metabolic balance and mitochondrial redox control, forming a persistent bioenergetic-redox bottleneck during repair. To target this defect, we engineered CM-NTU-Ce, a C2C12 membrane-coated nanothylakoid–ceria system that couples light-dependent ATP/NADPH generation with ceria-mediated redox buffering. In aged mice, CM-NTU-Ce improved mitochondrial fitness, restored ATP/ADP and NADPH/NADP⁺ ratios, enhanced myogenic progression and increased functional recovery after cardiotoxin-induced injury. Mechanistically, CM-NTU-Ce remodeled the macrophage compartment toward damaged-cell clearance-associated states; macrophage depletion attenuated the regenerative benefit, whereas CM-NTU-Ce-conditioned macrophages supported aged myoblast differentiation in transwell assays. Metabolomic profiling further confirmed restoration of mitochondrial and redox-associated metabolic pathways. These findings identify a recoverable bioenergetic-redox constraint that limits aged muscle repair and can be targeted to restore macrophage–myoblast coupling. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-12 |
| AnnouncementXML | Submission_2026-08-12_00:37:16.659.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Qi Cao |
| SpeciesList | scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | Q Exactive HF-X |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-12 00:36:43 | ID requested | |
| ⏵ 1 | 2026-08-12 00:37:17 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: muscle regeneration, macrophages |
Contact List
| Qi Cao | |
|---|---|
| contact affiliation | Naval Medical University |
| contact email | caoq@smmu.edu.cn |
| lab head | |
| Qi Cao | |
| contact affiliation | Naval Medical University |
| contact email | caoq@smmu.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
