⮝ Full datasets listing
PXD082322
PXD082322 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Harnessing the E3 Ligase KLHL12 for Tumor-selective Protein Degradation via Proteolysis-targeting Chimera Technology |
| Description | This project harnesses the E3 ligase KLHL12 for tumor-selective protein degradation. We designed and synthesized novel PROTACs , characterized their binding affinity and selectivity by biochemical assays, and performed quantitative proteomics to systematically evaluate degradation specificity, kinetics, and anti-tumor efficacy in cancer cell models. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-07 |
| AnnouncementXML | Submission_2026-08-07_00:08:02.326.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Shicheng Xu |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-07 00:07:44 | ID requested | |
| ⏵ 1 | 2026-08-07 00:08:02 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Tumor-selective Protein Degradation, KLHL12, E3 Ligase, PROTAC |
Contact List
| Zhengyu Jiang | |
|---|---|
| contact affiliation | China pharmaceutical university |
| contact email | jiangzhengyucpu@163.com |
| lab head | |
| Shicheng Xu | |
| contact affiliation | China pharmaceutical university |
| contact email | Xubin2690555782@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
