⮝ Full datasets listing
PXD082311
PXD082311 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | A Burkholderia nucleomodulin hijacks the NuRD complex to epigenetically suppress efferocytosis |
| Description | Burkholderia pseudomallei, the facultative intracellular pathogen that causes life-threatening melioidosis, delivers virulence effectors through secretion systems to subvert host-cell immunity, yet whether it deploys nuclear-targeted effectors to reprogram host immune responses remains unclear. Here, we identify BapC as a type III secretion system nucleomodulin that suppresses macrophage efferocytosis through epigenetic reprogramming. Mechanistically, BapC enters the host nucleus through an Asp95-dependent interaction with KPNB1. Nuclear BapC engages the Nucleosome Remodeling and Deacetylase (NuRD) complex to drive histone H3K18 deacetylation and repress efferocytosis-related genes. This epigenetic suppression impairs efferocytotic clearance of apoptotic cells by macrophages and promotes bacterial survival. Pharmacological inhibition of HDAC1/2, the deacetylase subunits of NuRD, restores efferocytosis and protects against lethal infection. Together, our study reveals how B. pseudomallei exploits a bacterial nucleomodulin to hijack a host chromatin corepressor complex and suppress innate immune clearance, suggesting HDAC inhibition as a potential host-directed therapeutic strategy for melioidosis. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-07 |
| AnnouncementXML | Submission_2026-08-06_18:49:03.092.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiheng Tang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; scientific name: Burkholderia pseudomallei K96243; NCBI TaxID: 272560; scientific name: Mus musculus; NCBI TaxID: 10090; |
| ModificationList | acetylated residue |
| Instrument | LTQ Orbitrap Velos; LTQ; Orbitrap Exploris 480; LTQ Orbitrap |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-06 18:46:55 | ID requested | |
| ⏵ 1 | 2026-08-06 18:49:03 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: Burkholderia, nucleomodulin, epigenetics, efferocytosis |
Contact List
| Qian Li | |
|---|---|
| contact affiliation | Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University), Chongqing, China |
| contact email | liqianjane@tmmu.edu.cn |
| lab head | |
| Zhiheng Tang | |
| contact affiliation | Department of Clinical Microbiology and Immunology, College of Pharmacy and Medical Laboratory, Army Medical University (Third Military Medical University), Chongqing, China |
| contact email | zhihengt@pku.edu.cn |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
