⮝ Full datasets listing
PXD082254
PXD082254 is an original dataset announced via ProteomeXchange.
Dataset Summary
| Title | Quantitative proteomics reveals time-dependent proteome changes in BEAS-2B cells induced by the FAK PROTAC M-3-3 |
| Description | Focal adhesion kinase (FAK) is a promising therapeutic target in various cancers. Here, we performed a time-resolved quantitative proteomic analysis to investigate the global protein expression changes in BEAS-2B cells following treatment with M-3-3, a PROTAC specifically targeting FAK. Cells were harvested at 0, 6, 12, and 24 hours post-treatment, and proteins were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). This dataset provides a comprehensive resource for understanding the kinetic degradation dynamics of FAK and the downstream signaling pathways modulated by PROTAC-mediated protein depletion. |
| HostingRepository | iProX |
| AnnounceDate | 2026-08-06 |
| AnnouncementXML | Submission_2026-08-06_00:57:42.535.xml |
| DigitalObjectIdentifier | |
| ReviewLevel | Peer-reviewed dataset |
| DatasetOrigin | Original dataset |
| RepositorySupport | Unsupported dataset by repository |
| PrimarySubmitter | Zhiying Wang |
| SpeciesList | scientific name: Homo sapiens; NCBI TaxID: 9606; |
| ModificationList | No PTMs are included in the dataset |
| Instrument | timsTOF HT |
Dataset History
| Revision | Datetime | Status | ChangeLog Entry |
|---|---|---|---|
| 0 | 2026-08-06 00:57:14 | ID requested | |
| ⏵ 1 | 2026-08-06 00:57:43 | announced |
Publication List
| Dataset with its publication pending |
Keyword List
| submitter keyword: FAK, Focal adhesion kinase, PROTAC |
Contact List
| Ting Dong | |
|---|---|
| contact affiliation | Institue of Materia Medica Chinese Academy of Medical Science |
| contact email | tingdong2025@pumc.edu.cn |
| lab head | |
| Zhiying Wang | |
| contact affiliation | Shandong University |
| contact email | wangzhiying7078@163.com |
| dataset submitter | |
Full Dataset Link List
| iProX dataset URI |
